Cargando…
Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases
Ischemic diseases, the leading cause of disability and death, are caused by the restriction or blockage of blood flow in specific tissues, including ischemic cardiac, ischemic cerebrovascular and ischemic peripheral vascular diseases. The regeneration of functional vasculature network in ischemic ti...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475455/ https://www.ncbi.nlm.nih.gov/pubmed/36168632 http://dx.doi.org/10.7150/thno.73421 |
_version_ | 1784789913349128192 |
---|---|
author | Zhuang, Jie Zhang, Xiangyun Liu, Qiqi Zhu, Mingsheng Huang, Xinglu |
author_facet | Zhuang, Jie Zhang, Xiangyun Liu, Qiqi Zhu, Mingsheng Huang, Xinglu |
author_sort | Zhuang, Jie |
collection | PubMed |
description | Ischemic diseases, the leading cause of disability and death, are caused by the restriction or blockage of blood flow in specific tissues, including ischemic cardiac, ischemic cerebrovascular and ischemic peripheral vascular diseases. The regeneration of functional vasculature network in ischemic tissues is essential for treatment of ischemic diseases. Direct delivery of pro-angiogenesis factors, such as VEGF, has demonstrated the effectiveness in ischemic disease therapy but suffering from several obstacles, such as low delivery efficacy in disease sites and uncontrolled modulation. In this review, we summarize the molecular mechanisms of inducing vascular regeneration, providing the guidance for designing the desired nanomedicines. We also introduce the delivery of various nanomedicines to ischemic tissues by passive or active targeting manner. To achieve the efficient delivery of nanomedicines in various ischemic diseases, we highlight targeted delivery of nanomedicines and controllable modulation of disease microenvironment using nanomedicines. |
format | Online Article Text |
id | pubmed-9475455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-94754552022-09-26 Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases Zhuang, Jie Zhang, Xiangyun Liu, Qiqi Zhu, Mingsheng Huang, Xinglu Theranostics Review Ischemic diseases, the leading cause of disability and death, are caused by the restriction or blockage of blood flow in specific tissues, including ischemic cardiac, ischemic cerebrovascular and ischemic peripheral vascular diseases. The regeneration of functional vasculature network in ischemic tissues is essential for treatment of ischemic diseases. Direct delivery of pro-angiogenesis factors, such as VEGF, has demonstrated the effectiveness in ischemic disease therapy but suffering from several obstacles, such as low delivery efficacy in disease sites and uncontrolled modulation. In this review, we summarize the molecular mechanisms of inducing vascular regeneration, providing the guidance for designing the desired nanomedicines. We also introduce the delivery of various nanomedicines to ischemic tissues by passive or active targeting manner. To achieve the efficient delivery of nanomedicines in various ischemic diseases, we highlight targeted delivery of nanomedicines and controllable modulation of disease microenvironment using nanomedicines. Ivyspring International Publisher 2022-08-29 /pmc/articles/PMC9475455/ /pubmed/36168632 http://dx.doi.org/10.7150/thno.73421 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Zhuang, Jie Zhang, Xiangyun Liu, Qiqi Zhu, Mingsheng Huang, Xinglu Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases |
title | Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases |
title_full | Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases |
title_fullStr | Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases |
title_full_unstemmed | Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases |
title_short | Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases |
title_sort | targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475455/ https://www.ncbi.nlm.nih.gov/pubmed/36168632 http://dx.doi.org/10.7150/thno.73421 |
work_keys_str_mv | AT zhuangjie targeteddeliveryofnanomedicinesforpromotingvascularregenerationinischemicdiseases AT zhangxiangyun targeteddeliveryofnanomedicinesforpromotingvascularregenerationinischemicdiseases AT liuqiqi targeteddeliveryofnanomedicinesforpromotingvascularregenerationinischemicdiseases AT zhumingsheng targeteddeliveryofnanomedicinesforpromotingvascularregenerationinischemicdiseases AT huangxinglu targeteddeliveryofnanomedicinesforpromotingvascularregenerationinischemicdiseases |