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Integrin β3-PKM2 pathway-mediated aerobic glycolysis contributes to mechanical ventilation-induced pulmonary fibrosis

Background: Mechanical ventilation (MV) can induce pulmonary fibrosis. This study aims to investigate whether MV-induced pulmonary fibrosis is associated with aerobic glycolysis and seeks to uncover the underlying mechanisms mediated by integrin β3-pyruvate kinase M2 (PKM2) pathway. Methods: PKM2 kn...

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Detalles Bibliográficos
Autores principales: Mei, Shuya, Xu, Qiaoyi, Hu, Yue, Tang, Ri, Feng, Jinhua, Zhou, Yang, Xing, Shunpeng, Gao, Yuan, He, Zhengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475464/
https://www.ncbi.nlm.nih.gov/pubmed/36168620
http://dx.doi.org/10.7150/thno.72328