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Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches (Adv. Sci. 26/2022)
Drug Repurposing Linked computational and experimental approaches identified that Xenopus laevis embryos can naturally tolerate certain bacteria by modulating their metal ion binding and hypoxia gene networks to maintain health despite high pathogen load. In article number 2200222, using natural tol...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475510/ http://dx.doi.org/10.1002/advs.202270166 |
| _version_ | 1784789923839082496 |
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| author | Sperry, Megan M. Novak, Richard Keshari, Vishal Dinis, Alexandre L. M. Cartwright, Mark J. Camacho, Diogo M. Paré, Jean‐François Super, Michael Levin, Michael Ingber, Donald E. |
| author_facet | Sperry, Megan M. Novak, Richard Keshari, Vishal Dinis, Alexandre L. M. Cartwright, Mark J. Camacho, Diogo M. Paré, Jean‐François Super, Michael Levin, Michael Ingber, Donald E. |
| author_sort | Sperry, Megan M. |
| collection | PubMed |
| description | Drug Repurposing Linked computational and experimental approaches identified that Xenopus laevis embryos can naturally tolerate certain bacteria by modulating their metal ion binding and hypoxia gene networks to maintain health despite high pathogen load. In article number 2200222, using natural tolerance mechanisms as inspiration, Megan Sperry, Richard Novak, Donald E. Ingber, and co‐workers induce an artificial tolerant state in susceptible Xenopus using drug repurposing. [Image: see text] |
| format | Online Article Text |
| id | pubmed-9475510 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94755102022-09-28 Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches (Adv. Sci. 26/2022) Sperry, Megan M. Novak, Richard Keshari, Vishal Dinis, Alexandre L. M. Cartwright, Mark J. Camacho, Diogo M. Paré, Jean‐François Super, Michael Levin, Michael Ingber, Donald E. Adv Sci (Weinh) Frontispiece Drug Repurposing Linked computational and experimental approaches identified that Xenopus laevis embryos can naturally tolerate certain bacteria by modulating their metal ion binding and hypoxia gene networks to maintain health despite high pathogen load. In article number 2200222, using natural tolerance mechanisms as inspiration, Megan Sperry, Richard Novak, Donald E. Ingber, and co‐workers induce an artificial tolerant state in susceptible Xenopus using drug repurposing. [Image: see text] John Wiley and Sons Inc. 2022-09-15 /pmc/articles/PMC9475510/ http://dx.doi.org/10.1002/advs.202270166 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Frontispiece Sperry, Megan M. Novak, Richard Keshari, Vishal Dinis, Alexandre L. M. Cartwright, Mark J. Camacho, Diogo M. Paré, Jean‐François Super, Michael Levin, Michael Ingber, Donald E. Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches (Adv. Sci. 26/2022) |
| title | Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches (Adv. Sci. 26/2022) |
| title_full | Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches (Adv. Sci. 26/2022) |
| title_fullStr | Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches (Adv. Sci. 26/2022) |
| title_full_unstemmed | Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches (Adv. Sci. 26/2022) |
| title_short | Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches (Adv. Sci. 26/2022) |
| title_sort | enhancers of host immune tolerance to bacterial infection discovered using linked computational and experimental approaches (adv. sci. 26/2022) |
| topic | Frontispiece |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475510/ http://dx.doi.org/10.1002/advs.202270166 |
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