Metal‐Free and Open‐Air Arylation Reactions of Diaryliodonium Salts for DNA‐Encoded Library Synthesis (Adv. Sci. 26/2022)

Meeting Diaryliodonium salts Chemistry with DNA‐Encoded Library DNA‐encoded library (DEL) is a powerful technique for hit discovery in medicinal chemistry. In article number 2202790, Hongtao Xu, Peixiang Ma, Wei Hou, Guang Yang, and co‐workers develope the first on‐DNA meeting diaryliodonium salts (...

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Detalles Bibliográficos
Autores principales: Xu, Hongtao, Tan, Tingting, Zhang, Yiyuan, Wang, Yan, Pan, Kangyin, Yao, Ying, Zhang, Shuning, Gu, Yuang, Chen, Wanting, Li, Jie, Dong, Hewei, Meng, Yu, Ma, Peixiang, Hou, Wei, Yang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475511/
http://dx.doi.org/10.1002/advs.202270165
Descripción
Sumario:Meeting Diaryliodonium salts Chemistry with DNA‐Encoded Library DNA‐encoded library (DEL) is a powerful technique for hit discovery in medicinal chemistry. In article number 2202790, Hongtao Xu, Peixiang Ma, Wei Hou, Guang Yang, and co‐workers develope the first on‐DNA meeting diaryliodonium salts (DAI) chemistry and realize the selective arylation of phenols and oximes with both high yield and DNA fidelity via substrate activation strategy. [Image: see text]

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