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The multifaceted functions of cGAS
Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475664/ https://www.ncbi.nlm.nih.gov/pubmed/35536585 http://dx.doi.org/10.1093/jmcb/mjac031 |
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author | Liu, Haipeng Wang, Fei Cao, Yajuan Dang, Yifang Ge, Baoxue |
author_facet | Liu, Haipeng Wang, Fei Cao, Yajuan Dang, Yifang Ge, Baoxue |
author_sort | Liu, Haipeng |
collection | PubMed |
description | Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a major cytosolic DNA receptor is a milestone in the field of DNA sensing. The engagement of cGAS by double-stranded DNA from different origins, including invading pathogens, damaged mitochondria, ruptured micronuclei, and genomic DNA results in the generation of cGAMP and activation of stimulator of interferon genes, which thereby activates innate immunity mainly characterized by the activation of type I interferon response. In recent years, great progress has been made in understanding the subcellular localization and novel functions of cGAS. In this review, we particularly focus on summarizing the multifaceted roles of cGAS in regulating senescence, autophagy, cell stemness, apoptosis, angiogenesis, cell proliferation, antitumor effect, DNA replication, DNA damage repair, micronucleophagy, as well as cell metabolism. |
format | Online Article Text |
id | pubmed-9475664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-94756642022-09-19 The multifaceted functions of cGAS Liu, Haipeng Wang, Fei Cao, Yajuan Dang, Yifang Ge, Baoxue J Mol Cell Biol Review Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a major cytosolic DNA receptor is a milestone in the field of DNA sensing. The engagement of cGAS by double-stranded DNA from different origins, including invading pathogens, damaged mitochondria, ruptured micronuclei, and genomic DNA results in the generation of cGAMP and activation of stimulator of interferon genes, which thereby activates innate immunity mainly characterized by the activation of type I interferon response. In recent years, great progress has been made in understanding the subcellular localization and novel functions of cGAS. In this review, we particularly focus on summarizing the multifaceted roles of cGAS in regulating senescence, autophagy, cell stemness, apoptosis, angiogenesis, cell proliferation, antitumor effect, DNA replication, DNA damage repair, micronucleophagy, as well as cell metabolism. Oxford University Press 2022-05-10 /pmc/articles/PMC9475664/ /pubmed/35536585 http://dx.doi.org/10.1093/jmcb/mjac031 Text en © The Author(s) (2022). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Liu, Haipeng Wang, Fei Cao, Yajuan Dang, Yifang Ge, Baoxue The multifaceted functions of cGAS |
title | The multifaceted functions of cGAS |
title_full | The multifaceted functions of cGAS |
title_fullStr | The multifaceted functions of cGAS |
title_full_unstemmed | The multifaceted functions of cGAS |
title_short | The multifaceted functions of cGAS |
title_sort | multifaceted functions of cgas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475664/ https://www.ncbi.nlm.nih.gov/pubmed/35536585 http://dx.doi.org/10.1093/jmcb/mjac031 |
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