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Clozapine-induced parotitis: A case study
INTRODUCTION: Clozapine is the drug of choice for patients with an unsatisfactory response to classic antipsychotic treatment. Little is known about the involvement of clozapine in the development of parotid disease. OBJECTIVES: Identify the clinical characteristics of Clozapine-induced parotitis th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475681/ http://dx.doi.org/10.1192/j.eurpsy.2021.1433 |
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author | Kacem, M. Mami, H. Sellami, S. Moalla, M. Frej, S. Ben Bouzid, R. |
author_facet | Kacem, M. Mami, H. Sellami, S. Moalla, M. Frej, S. Ben Bouzid, R. |
author_sort | Kacem, M. |
collection | PubMed |
description | INTRODUCTION: Clozapine is the drug of choice for patients with an unsatisfactory response to classic antipsychotic treatment. Little is known about the involvement of clozapine in the development of parotid disease. OBJECTIVES: Identify the clinical characteristics of Clozapine-induced parotitis through a case and literature review. METHODS: We report the case of a patient with a refractory schizoaffective disorder, bipolar type and who developed recurrent parotitis while taking clozapine. We conducted a literature review based on a PubMed search of articles published on this subject with the following keywords: ‘parotitis clozapine’. RESULTS: Miss W., 34 years old, suffers from a severe schizoaffective disorder that has been diagnosed for several years. She has received various psychotropic medications. She suffered from frequent relapses that required recurrent hospital admissions. One year ago, a diagnosis of treatment-resistant schizoaffective disorder was made. The decision to introduce clozapine, associated with mood stabilizer treatment, was made on the basis of her treatment refractory symptoms. She experienced considerable sialorrhea after beginning clozapine treatment. Miss W. developed bilateral recurrent swelling over both temporal-mandibular areas after 6 months of treatment. It often appears after eating and lasts from 4 to 6 hours. There was no change in white blood cell count and she was afebrile. An otolaryngologist was consulted and a diagnosis of clozapine-induced parotitis was suggested. A spasmolytic and an anticholinergic treatment were prescribed and clozapine was continued. CONCLUSIONS: This iatrogenic effect of clozapine must be recognized by clinicians in order to be better prevented. |
format | Online Article Text |
id | pubmed-9475681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-94756812022-09-29 Clozapine-induced parotitis: A case study Kacem, M. Mami, H. Sellami, S. Moalla, M. Frej, S. Ben Bouzid, R. Eur Psychiatry Abstract INTRODUCTION: Clozapine is the drug of choice for patients with an unsatisfactory response to classic antipsychotic treatment. Little is known about the involvement of clozapine in the development of parotid disease. OBJECTIVES: Identify the clinical characteristics of Clozapine-induced parotitis through a case and literature review. METHODS: We report the case of a patient with a refractory schizoaffective disorder, bipolar type and who developed recurrent parotitis while taking clozapine. We conducted a literature review based on a PubMed search of articles published on this subject with the following keywords: ‘parotitis clozapine’. RESULTS: Miss W., 34 years old, suffers from a severe schizoaffective disorder that has been diagnosed for several years. She has received various psychotropic medications. She suffered from frequent relapses that required recurrent hospital admissions. One year ago, a diagnosis of treatment-resistant schizoaffective disorder was made. The decision to introduce clozapine, associated with mood stabilizer treatment, was made on the basis of her treatment refractory symptoms. She experienced considerable sialorrhea after beginning clozapine treatment. Miss W. developed bilateral recurrent swelling over both temporal-mandibular areas after 6 months of treatment. It often appears after eating and lasts from 4 to 6 hours. There was no change in white blood cell count and she was afebrile. An otolaryngologist was consulted and a diagnosis of clozapine-induced parotitis was suggested. A spasmolytic and an anticholinergic treatment were prescribed and clozapine was continued. CONCLUSIONS: This iatrogenic effect of clozapine must be recognized by clinicians in order to be better prevented. Cambridge University Press 2021-08-13 /pmc/articles/PMC9475681/ http://dx.doi.org/10.1192/j.eurpsy.2021.1433 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Kacem, M. Mami, H. Sellami, S. Moalla, M. Frej, S. Ben Bouzid, R. Clozapine-induced parotitis: A case study |
title | Clozapine-induced parotitis: A case study |
title_full | Clozapine-induced parotitis: A case study |
title_fullStr | Clozapine-induced parotitis: A case study |
title_full_unstemmed | Clozapine-induced parotitis: A case study |
title_short | Clozapine-induced parotitis: A case study |
title_sort | clozapine-induced parotitis: a case study |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475681/ http://dx.doi.org/10.1192/j.eurpsy.2021.1433 |
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