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FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer

BACKGROUND: Activation of the programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) pathway has been extensively described as a pivotal mechanism to escape immune surveillance and elicits suppressive effect on antitumor immunity. Blockade of the PD-1/PD-L1 interaction by checkpoint...

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Detalles Bibliográficos
Autores principales:	Liu, Jiaxin, Wei, Lingyun, Hu, Nan, Wang, Dong, Ni, Juan, Zhang, Sha, Liu, Hongbing, Lv, Tangfeng, Yin, Jie, Ye, Mingxiang, Song, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476142/ https://www.ncbi.nlm.nih.gov/pubmed/36104103 http://dx.doi.org/10.1136/jitc-2022-005116

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