Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted (19)F NMR Spectroscopy

[Image: see text] With renewed interest in atropisomerism of drug molecules, efficient methods to experimentally determine torsion rotational energy barriers are needed. Here, we describe use of the chiral phosphoric acid solvating agent (+)-TiPSY to resolve the signals of atropisomers in (19)F NMR...

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Detalles Bibliográficos
Autores principales: Kulyk, Svitlana, De Paul, Susan M., Marx, Matthew A., Peakman, Torren M., Smith, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476184/
https://www.ncbi.nlm.nih.gov/pubmed/36120049
http://dx.doi.org/10.1021/acsomega.2c03316

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