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Surface-Coated Cerium Nanoparticles to Improve Chemotherapeutic Delivery to Tumor Cells
[Image: see text] The antioxidant property of cerium oxide nanoparticles has increased their demand as a nanocarrier to improve the delivery and therapeutic efficacy of anticancer drugs. Here, we report the synthesis of alginate-coated ceria nanoformulations (ceria NPs) and characterization using FT...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476200/ https://www.ncbi.nlm.nih.gov/pubmed/36120021 http://dx.doi.org/10.1021/acsomega.2c00062 |
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author | Pramanik, Nilkamal De, Tamasa Sharma, Preeti Alakesh, Alakesh Jagirdar, Sameer Kumar Rangarajan, Annapoorni Jhunjhunwala, Siddharth |
author_facet | Pramanik, Nilkamal De, Tamasa Sharma, Preeti Alakesh, Alakesh Jagirdar, Sameer Kumar Rangarajan, Annapoorni Jhunjhunwala, Siddharth |
author_sort | Pramanik, Nilkamal |
collection | PubMed |
description | [Image: see text] The antioxidant property of cerium oxide nanoparticles has increased their demand as a nanocarrier to improve the delivery and therapeutic efficacy of anticancer drugs. Here, we report the synthesis of alginate-coated ceria nanoformulations (ceria NPs) and characterization using FTIR spectroscopy, Raman microscopy, and X-ray diffraction. The synthesized ceria NPs show negligible inherent in vitro toxicity when tested on a MDA-MB-231 breast cancer cell line at higher particle concentrations. Upon loading these particles with doxorubicin (Dox) and paclitaxel (PTX) drugs, we observe a potential synergistic cytotoxic effect mediated by the drug and the ceria NPs, resulting in the better killing capacity as well as suppression of cell migration against the MDA-MB-231 cell line. Further, to verify the immune-escaping capacity before targeting cancer cells, we coated the drug-loaded ceria NPs with the membrane of MDA-MB-231 cells using an extrusion method. The resultant delivery system exhibited in vitro preferential uptake by the MDA-MB-231 cell line and showed reduced uptake by the murine macrophage cell line (RAW 264.7), assigning its potential application as non-immunogenic personalized therapy in targeting and killing of cancer cells. |
format | Online Article Text |
id | pubmed-9476200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94762002022-09-16 Surface-Coated Cerium Nanoparticles to Improve Chemotherapeutic Delivery to Tumor Cells Pramanik, Nilkamal De, Tamasa Sharma, Preeti Alakesh, Alakesh Jagirdar, Sameer Kumar Rangarajan, Annapoorni Jhunjhunwala, Siddharth ACS Omega [Image: see text] The antioxidant property of cerium oxide nanoparticles has increased their demand as a nanocarrier to improve the delivery and therapeutic efficacy of anticancer drugs. Here, we report the synthesis of alginate-coated ceria nanoformulations (ceria NPs) and characterization using FTIR spectroscopy, Raman microscopy, and X-ray diffraction. The synthesized ceria NPs show negligible inherent in vitro toxicity when tested on a MDA-MB-231 breast cancer cell line at higher particle concentrations. Upon loading these particles with doxorubicin (Dox) and paclitaxel (PTX) drugs, we observe a potential synergistic cytotoxic effect mediated by the drug and the ceria NPs, resulting in the better killing capacity as well as suppression of cell migration against the MDA-MB-231 cell line. Further, to verify the immune-escaping capacity before targeting cancer cells, we coated the drug-loaded ceria NPs with the membrane of MDA-MB-231 cells using an extrusion method. The resultant delivery system exhibited in vitro preferential uptake by the MDA-MB-231 cell line and showed reduced uptake by the murine macrophage cell line (RAW 264.7), assigning its potential application as non-immunogenic personalized therapy in targeting and killing of cancer cells. American Chemical Society 2022-09-01 /pmc/articles/PMC9476200/ /pubmed/36120021 http://dx.doi.org/10.1021/acsomega.2c00062 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Pramanik, Nilkamal De, Tamasa Sharma, Preeti Alakesh, Alakesh Jagirdar, Sameer Kumar Rangarajan, Annapoorni Jhunjhunwala, Siddharth Surface-Coated Cerium Nanoparticles to Improve Chemotherapeutic Delivery to Tumor Cells |
title | Surface-Coated
Cerium Nanoparticles to Improve Chemotherapeutic
Delivery to Tumor Cells |
title_full | Surface-Coated
Cerium Nanoparticles to Improve Chemotherapeutic
Delivery to Tumor Cells |
title_fullStr | Surface-Coated
Cerium Nanoparticles to Improve Chemotherapeutic
Delivery to Tumor Cells |
title_full_unstemmed | Surface-Coated
Cerium Nanoparticles to Improve Chemotherapeutic
Delivery to Tumor Cells |
title_short | Surface-Coated
Cerium Nanoparticles to Improve Chemotherapeutic
Delivery to Tumor Cells |
title_sort | surface-coated
cerium nanoparticles to improve chemotherapeutic
delivery to tumor cells |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476200/ https://www.ncbi.nlm.nih.gov/pubmed/36120021 http://dx.doi.org/10.1021/acsomega.2c00062 |
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