Discovery of Novel Inhibitors of Bacterial DNA Gyrase Using a QSAR-Based Approach

[Image: see text] Type II topoisomerases like DNA gyrase initiate ATP-dependent negative supercoils in bacterial DNA. It is critical in all of the bacteria but is missing from eukaryotes, making it a striking target for antibacterials. Ciprofloxacin is a clinically approved drug, but its clinical ef...

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Detalles Bibliográficos
Autores principales: Jakhar, Ritu, Khichi, Alka, Kumar, Dev, Dangi, Mehak, Chhillar, Anil Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476201/
https://www.ncbi.nlm.nih.gov/pubmed/36120069
http://dx.doi.org/10.1021/acsomega.2c04310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476201/
https://www.ncbi.nlm.nih.gov/pubmed/36120069
http://dx.doi.org/10.1021/acsomega.2c04310

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