Cargando…

Discovery of Novel Inhibitors of Bacterial DNA Gyrase Using a QSAR-Based Approach

[Image: see text] Type II topoisomerases like DNA gyrase initiate ATP-dependent negative supercoils in bacterial DNA. It is critical in all of the bacteria but is missing from eukaryotes, making it a striking target for antibacterials. Ciprofloxacin is a clinically approved drug, but its clinical ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jakhar, Ritu, Khichi, Alka, Kumar, Dev, Dangi, Mehak, Chhillar, Anil Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476201/ https://www.ncbi.nlm.nih.gov/pubmed/36120069 http://dx.doi.org/10.1021/acsomega.2c04310

Ejemplares similares

Advanced In Silico Tools for Designing of Antigenic Epitope as Potential Vaccine Candidates Against Coronavirus
por: Dangi, Mehak, et al.
Publicado: (2018)

Identification of novel bacterial DNA gyrase inhibitors: An in silico study
por: Rahimi, Hamzeh, et al.
Publicado: (2016)

Application of a Novel Microtitre Plate-Based Assay for the Discovery of New Inhibitors of DNA Gyrase and DNA Topoisomerase VI
por: Taylor, James A., et al.
Publicado: (2013)

Discovery of Furanoquinone Derivatives as a Novel Class of DNA Polymerase and Gyrase Inhibitors for MRSA Eradication in Cutaneous Infection
por: Yang, Shih-Chun, et al.
Publicado: (2019)

Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site
por: Franco-Ulloa, Sebastian, et al.
Publicado: (2018)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
por: Grossman, Scott, et al.
Publicado: (2023)

The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action
por: Karkare, Shantanu, et al.
Publicado: (2013)

Modulated control of DNA supercoiling balance by the DNA-wrapping domain of bacterial gyrase
por: Hobson, Matthew J, et al.
Publicado: (2020)

Vibrio cholerae ParE2 Poisons DNA Gyrase via a Mechanism Distinct from Other Gyrase Inhibitors
por: Yuan, Jie, et al.
Publicado: (2010)

Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening
por: Sayed, Ahmed M., et al.
Publicado: (2020)

QSAR Accelerated Discovery of Potent Ice Recrystallization Inhibitors
por: Briard, Jennie G., et al.
Publicado: (2016)

Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase
por: Henderson, Sara R, et al.
Publicado: (2020)

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation
por: Durcik, Martina, et al.
Publicado: (2020)

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors
por: Skok, Žiga, et al.
Publicado: (2020)

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives
por: Collin, Frédéric, et al.
Publicado: (2011)

Gyramides Prevent Bacterial Growth by Inhibiting DNA Gyrase and Altering Chromosome Topology
por: Rajendram, Manohary, et al.
Publicado: (2014)

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation
por: McAuley, Scott, et al.
Publicado: (2019)

Solution structures of DNA-bound gyrase
por: Baker, Nicole M., et al.
Publicado: (2011)

DNA Gyrase as a Target for Quinolones
por: Spencer, Angela C., et al.
Publicado: (2023)

Computational Identification of Inhibitors Using QSAR Approach Against Nipah Virus
por: Rajput, Akanksha, et al.
Publicado: (2019)

QSAR and molecular docking for the search of AOX inhibitors: a rational drug discovery approach
por: Rosell-Hidalgo, Alicia, et al.
Publicado: (2020)

Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks
por: Dauda, Soziema E., et al.
Publicado: (2023)

An In-Silico Evaluation of Anthraquinones as Potential Inhibitors of DNA Gyrase B of Mycobacterium tuberculosis
por: Amorim, Juliana Carolina, et al.
Publicado: (2022)

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase
por: Ahmed, Wareed, et al.
Publicado: (2017)

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
por: Cotman, Andrej Emanuel, et al.
Publicado: (2023)

Structural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomerase
por: Papillon, Julie, et al.
Publicado: (2013)

Methylene Diphosphonate Bone Scan Scintigraphic Image Enhancement using Gamma Correction and Optimizing the Value of Gamma
por: Sharma, Anshul, et al.
Publicado: (2020)

YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase
por: Sengupta, Sugopa, et al.
Publicado: (2008)

Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores
por: Tomašič, Tihomir, et al.
Publicado: (2021)

A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus
por: Ganapathy, Uday S., et al.
Publicado: (2021)

Comparative Molecular docking analysis of DNA Gyrase subunit A in Pseudomonas aeruginosaPAO1
por: Gupta, Aman, et al.
Publicado: (2013)

Fragments of the Bacterial Toxin Microcin B17 as Gyrase Poisons
por: Collin, Frédéric, et al.
Publicado: (2013)

Pharmacophore modeling, docking and the integrated use of a ligand- and structure-based virtual screening approach for novel DNA gyrase inhibitors: synthetic and biological evaluation studies
por: Mathpal, Deepti, et al.
Publicado: (2021)

High-throughput assays for DNA gyrase and other topoisomerases
por: Maxwell, Anthony, et al.
Publicado: (2006)

Inhibition of translesion DNA polymerase by archaeal reverse gyrase
por: Valenti, Anna, et al.
Publicado: (2009)

The role of monovalent cations in the ATPase reaction of DNA gyrase
por: Hearnshaw, Stephen James, et al.
Publicado: (2015)

Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase
por: Ashley, Rachel E., et al.
Publicado: (2017)

Activities of gyrase and topoisomerase IV on positively supercoiled DNA
por: Ashley, Rachel E., et al.
Publicado: (2017)

First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of SPR720, a Novel Oral Bacterial DNA Gyrase (GyrB) Inhibitor for Mycobacterial Infections
por: Talley, Angela K., et al.
Publicado: (2021)

QSAR-driven rational design of novel DNA methyltransferase 1 inhibitors
por: Phanus-umporn, Chuleeporn, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4mb8aejmtscr07v5iosf5cv3l7