Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer’s Disease

[Image: see text] The pathogenesis of Alzheimer’s disease (AD) is very complex, and there are many hypotheses. Therefore, the development of a multi-target-directed-ligand may be an effective therapeutic strategy. Our previous study showed that notopterol (a natural product from Notopterygium) is a...

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Detalles Bibliográficos
Autores principales: Wang, Nan, Liu, Wenjie, Zhou, Lijun, Liu, Wenwu, Liang, Xu, Liu, Xin, Xu, Zihua, Zhong, Tianming, Wu, Qiong, Jiao, Xinming, Chen, Jiangxia, Ning, Xinyue, Jiang, Xiaowen, Zhao, Qingchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476211/
https://www.ncbi.nlm.nih.gov/pubmed/36120034
http://dx.doi.org/10.1021/acsomega.2c03368

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