Update meta-analysis from biomedical literature about MTHFR’polymorphisms and the CML’ risk

Background: The MTHFR gene polymorphisms are closely related to the chronic myeloid leukemia (CML). Case-control studies have associated the MTHFR polymorphisms and susceptibility to CML but the results were not conclusive. The aim of this study was to assess this association through an update meta-analysis. Methods: Electronic searches were conducted to select published studies prior to juin 2018. Pooled odds ratios (OR) with corresponding 95% confidence interval (95% CI) and stratification analysis were performed under different genetic comparison models and ethnicity. Results: Totally, 17 and 12 case-control studies including CML cases and controls were enrolled in the meta-analysis respectively for C677T and A1298C polymorphism and CML risk. A poor association between the C677T (T vs C ; OR= 1,28; IC95%= [1,01;1,63]; p=0,04) and the one not significant between the A1298C (C vs A ; OR= 1,52; IC95%= [0,92; 2,51]; p= 0,1)polymorphisms and the CML risk for overall population were found. Conclusions: the results of this meta-analysis suggested no significant association between C677T and A1298C polymorphisms and CML risk leading to consider other factors such us folic acid intake, gene-gene and gene- environment interactions.