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CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease

BACKGROUND: Aberrant DNA methylation patterns have been observed in neurodegenerative diseases, including Alzheimer's disease (AD), and dynamic changes in DNA methylation are closely associated with the onset and progression of these diseases. Particularly, hypomethylation of the amyloid precur...

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Detalles Bibliográficos
Autores principales:	Park, Hanseul, Shin, Jaein, Kim, Yunkyung, Saito, Takashi, Saido, Takaomi C., Kim, Jongpil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476342/ https://www.ncbi.nlm.nih.gov/pubmed/36109806 http://dx.doi.org/10.1186/s40035-022-00314-0

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