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A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation

A potentially active water-soluble anti-viral with lesser toxic material from the Oseltamivir (OTV) has been produced by the sonication method. The formed material has been further characterized by UV–visible, FT-IR, powder XRD, SEM, TGA/DTA, ROESY, XPS, AFM and etc., The results of DFT calculation...

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Autores principales: Rajamohan, Rajaram, Mohandoss, Sonaimuthu, Ashokkumar, Sekar, Madi, Fatiha, Leila, Neour, Murugavel, Kuppusamy, Lee, Yong Rok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476363/
https://www.ncbi.nlm.nih.gov/pubmed/36126612
http://dx.doi.org/10.1016/j.jpba.2022.115057
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author Rajamohan, Rajaram
Mohandoss, Sonaimuthu
Ashokkumar, Sekar
Madi, Fatiha
Leila, Neour
Murugavel, Kuppusamy
Lee, Yong Rok
author_facet Rajamohan, Rajaram
Mohandoss, Sonaimuthu
Ashokkumar, Sekar
Madi, Fatiha
Leila, Neour
Murugavel, Kuppusamy
Lee, Yong Rok
author_sort Rajamohan, Rajaram
collection PubMed
description A potentially active water-soluble anti-viral with lesser toxic material from the Oseltamivir (OTV) has been produced by the sonication method. The formed material has been further characterized by UV–visible, FT-IR, powder XRD, SEM, TGA/DTA, ROESY, XPS, AFM and etc., The results of DFT calculation have proven that inclusion complexes (ICs) are theoretically and energetically more advantageous models and structures have also been proposed based on the results. Analysis of drug release has been carried out at three pH levels, and it is revealed the analysis is most helpful at acidic pH levels for the ICs with S-CD over H-CD. Over OTV without CDs, OTV:S-CD-ICs exhibited a very less cytotoxic ability on cancer cell lines than ICs with M-CD. ICs enhanced the coronavirus inactivation nature of OTV. This study provides for the first time a full characterization of ICs of OTV with CDs and highlights the impact of complexation on pharmacological activity.
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spelling pubmed-94763632022-09-15 A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation Rajamohan, Rajaram Mohandoss, Sonaimuthu Ashokkumar, Sekar Madi, Fatiha Leila, Neour Murugavel, Kuppusamy Lee, Yong Rok J Pharm Biomed Anal Article A potentially active water-soluble anti-viral with lesser toxic material from the Oseltamivir (OTV) has been produced by the sonication method. The formed material has been further characterized by UV–visible, FT-IR, powder XRD, SEM, TGA/DTA, ROESY, XPS, AFM and etc., The results of DFT calculation have proven that inclusion complexes (ICs) are theoretically and energetically more advantageous models and structures have also been proposed based on the results. Analysis of drug release has been carried out at three pH levels, and it is revealed the analysis is most helpful at acidic pH levels for the ICs with S-CD over H-CD. Over OTV without CDs, OTV:S-CD-ICs exhibited a very less cytotoxic ability on cancer cell lines than ICs with M-CD. ICs enhanced the coronavirus inactivation nature of OTV. This study provides for the first time a full characterization of ICs of OTV with CDs and highlights the impact of complexation on pharmacological activity. Elsevier B.V. 2022-11-30 2022-09-15 /pmc/articles/PMC9476363/ /pubmed/36126612 http://dx.doi.org/10.1016/j.jpba.2022.115057 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rajamohan, Rajaram
Mohandoss, Sonaimuthu
Ashokkumar, Sekar
Madi, Fatiha
Leila, Neour
Murugavel, Kuppusamy
Lee, Yong Rok
A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation
title A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation
title_full A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation
title_fullStr A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation
title_full_unstemmed A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation
title_short A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation
title_sort novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476363/
https://www.ncbi.nlm.nih.gov/pubmed/36126612
http://dx.doi.org/10.1016/j.jpba.2022.115057
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