Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study

BACKGROUND: This pilot study included 68 cases with post-COVID-19 persistent cough (> 8 weeks), randomly allocated into two groups; intervention group (32 patients) received standard cough therapy, and montelukast 10 mg/day for 14 days and control group (36 patients) received only cough sedatives...

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Autores principales: Mohamed Hussein, Aliae A. R., Ibrahim, Mohamed Eltaher A. A., Makhlouf, Hoda A., Makhlouf, Nahed A., Abd-Elaal, Howaida K., Kholief, Karima M. S., Sayed, Islam G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476462/
http://dx.doi.org/10.1186/s43168-022-00154-6
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author Mohamed Hussein, Aliae A. R.
Ibrahim, Mohamed Eltaher A. A.
Makhlouf, Hoda A.
Makhlouf, Nahed A.
Abd-Elaal, Howaida K.
Kholief, Karima M. S.
Sayed, Islam G.
author_facet Mohamed Hussein, Aliae A. R.
Ibrahim, Mohamed Eltaher A. A.
Makhlouf, Hoda A.
Makhlouf, Nahed A.
Abd-Elaal, Howaida K.
Kholief, Karima M. S.
Sayed, Islam G.
author_sort Mohamed Hussein, Aliae A. R.
collection PubMed
description BACKGROUND: This pilot study included 68 cases with post-COVID-19 persistent cough (> 8 weeks), randomly allocated into two groups; intervention group (32 patients) received standard cough therapy, and montelukast 10 mg/day for 14 days and control group (36 patients) received only cough sedatives. RESULTS: We found a significant improvement in the number of cough paroxysms/day, cough severity visual analog scale, cough severity index and cough quality of life, shorter duration improvement, and minimal side effects in the interventional group. CONCLUSIONS: We suggest that montelukast may be effective to reduce the duration and severity of the persistent post-COVID-19 cough and further improve quality of life.
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spelling pubmed-94764622022-09-15 Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study Mohamed Hussein, Aliae A. R. Ibrahim, Mohamed Eltaher A. A. Makhlouf, Hoda A. Makhlouf, Nahed A. Abd-Elaal, Howaida K. Kholief, Karima M. S. Sayed, Islam G. Egypt J Bronchol Research BACKGROUND: This pilot study included 68 cases with post-COVID-19 persistent cough (> 8 weeks), randomly allocated into two groups; intervention group (32 patients) received standard cough therapy, and montelukast 10 mg/day for 14 days and control group (36 patients) received only cough sedatives. RESULTS: We found a significant improvement in the number of cough paroxysms/day, cough severity visual analog scale, cough severity index and cough quality of life, shorter duration improvement, and minimal side effects in the interventional group. CONCLUSIONS: We suggest that montelukast may be effective to reduce the duration and severity of the persistent post-COVID-19 cough and further improve quality of life. Springer Berlin Heidelberg 2022-09-15 2022 /pmc/articles/PMC9476462/ http://dx.doi.org/10.1186/s43168-022-00154-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Mohamed Hussein, Aliae A. R.
Ibrahim, Mohamed Eltaher A. A.
Makhlouf, Hoda A.
Makhlouf, Nahed A.
Abd-Elaal, Howaida K.
Kholief, Karima M. S.
Sayed, Islam G.
Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study
title Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study
title_full Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study
title_fullStr Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study
title_full_unstemmed Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study
title_short Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study
title_sort value of montelukast as a potential treatment of post-covid-19 persistent cough: a non-randomized controlled pilot study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476462/
http://dx.doi.org/10.1186/s43168-022-00154-6
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