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Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations

[Image: see text] Spiroindolines represent a privileged structure in medicinal chemistry, although stereocontrol around the spirocarbon can be a synthetic challenge. Here we present a palladium(0)-catalyzed intramolecular Mizoroki–Heck annulation reaction from (+)-Vince lactam-derived cyclopentenyl-...

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Detalles Bibliográficos
Autores principales:	Lindman, Jens, Gopalan, Greeshma, Palo-Nieto, Carlos, Brandt, Peter, Gising, Johan, Larhed, Mats
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476516/ https://www.ncbi.nlm.nih.gov/pubmed/36120037 http://dx.doi.org/10.1021/acsomega.2c04111

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