Cargando…
Rapid Characterization of Solid Tumors Using Resonant Sensors
[Image: see text] Cancer continues to be a significant cause of non-traumatic pediatric mortality. Diagnosis of pediatric solid tumors is paramount to prescribing the correct treatment regimen. Recent efforts have focused on non-invasive methods to obtain tumor tissues, but one of the challenges enc...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476530/ https://www.ncbi.nlm.nih.gov/pubmed/36119978 http://dx.doi.org/10.1021/acsomega.2c04345 |
_version_ | 1784790159330377728 |
---|---|
author | Beierle, Andee M. Quinn, Colin H. Markert, Hooper R. Carr, Adam Marayati, Raoud Bownes, Laura V. Hutchins, Sara Claire Stewart, Jerry E. Hill, Benjamin Ohlmeyer, Michael Reuel, Nigel F. Beierle, Elizabeth A. |
author_facet | Beierle, Andee M. Quinn, Colin H. Markert, Hooper R. Carr, Adam Marayati, Raoud Bownes, Laura V. Hutchins, Sara Claire Stewart, Jerry E. Hill, Benjamin Ohlmeyer, Michael Reuel, Nigel F. Beierle, Elizabeth A. |
author_sort | Beierle, Andee M. |
collection | PubMed |
description | [Image: see text] Cancer continues to be a significant cause of non-traumatic pediatric mortality. Diagnosis of pediatric solid tumors is paramount to prescribing the correct treatment regimen. Recent efforts have focused on non-invasive methods to obtain tumor tissues, but one of the challenges encountered is the ability to obtain an adequate amount of viable tissue. In this study, a wireless, inductor-capacitor (LC) sensor was employed to detect relative permittivity of pediatric tumor tissues. There is a comparison of resonant frequencies of tumor tissues between live versus dead tissues, the primary tumor tissue versus tissue from the organs of origin or metastasis, and treated versus untreated tumors. The results show significant shifts in resonant frequencies between the comparison groups. Dead tissues demonstrated a significant shift in resonant frequencies compared to alive tissues. There were significant differences between the resonant frequencies of normal tissues versus tumor tissues. Resonant frequencies were also significantly different between primary tumors compared to their respective metastases. These data indicate that there are potential clinical applications of LC technology in the detection and diagnosis of pediatric solid tumors. |
format | Online Article Text |
id | pubmed-9476530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94765302022-09-16 Rapid Characterization of Solid Tumors Using Resonant Sensors Beierle, Andee M. Quinn, Colin H. Markert, Hooper R. Carr, Adam Marayati, Raoud Bownes, Laura V. Hutchins, Sara Claire Stewart, Jerry E. Hill, Benjamin Ohlmeyer, Michael Reuel, Nigel F. Beierle, Elizabeth A. ACS Omega [Image: see text] Cancer continues to be a significant cause of non-traumatic pediatric mortality. Diagnosis of pediatric solid tumors is paramount to prescribing the correct treatment regimen. Recent efforts have focused on non-invasive methods to obtain tumor tissues, but one of the challenges encountered is the ability to obtain an adequate amount of viable tissue. In this study, a wireless, inductor-capacitor (LC) sensor was employed to detect relative permittivity of pediatric tumor tissues. There is a comparison of resonant frequencies of tumor tissues between live versus dead tissues, the primary tumor tissue versus tissue from the organs of origin or metastasis, and treated versus untreated tumors. The results show significant shifts in resonant frequencies between the comparison groups. Dead tissues demonstrated a significant shift in resonant frequencies compared to alive tissues. There were significant differences between the resonant frequencies of normal tissues versus tumor tissues. Resonant frequencies were also significantly different between primary tumors compared to their respective metastases. These data indicate that there are potential clinical applications of LC technology in the detection and diagnosis of pediatric solid tumors. American Chemical Society 2022-09-02 /pmc/articles/PMC9476530/ /pubmed/36119978 http://dx.doi.org/10.1021/acsomega.2c04345 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Beierle, Andee M. Quinn, Colin H. Markert, Hooper R. Carr, Adam Marayati, Raoud Bownes, Laura V. Hutchins, Sara Claire Stewart, Jerry E. Hill, Benjamin Ohlmeyer, Michael Reuel, Nigel F. Beierle, Elizabeth A. Rapid Characterization of Solid Tumors Using Resonant Sensors |
title | Rapid Characterization
of Solid Tumors Using Resonant
Sensors |
title_full | Rapid Characterization
of Solid Tumors Using Resonant
Sensors |
title_fullStr | Rapid Characterization
of Solid Tumors Using Resonant
Sensors |
title_full_unstemmed | Rapid Characterization
of Solid Tumors Using Resonant
Sensors |
title_short | Rapid Characterization
of Solid Tumors Using Resonant
Sensors |
title_sort | rapid characterization
of solid tumors using resonant
sensors |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476530/ https://www.ncbi.nlm.nih.gov/pubmed/36119978 http://dx.doi.org/10.1021/acsomega.2c04345 |
work_keys_str_mv | AT beierleandeem rapidcharacterizationofsolidtumorsusingresonantsensors AT quinncolinh rapidcharacterizationofsolidtumorsusingresonantsensors AT markerthooperr rapidcharacterizationofsolidtumorsusingresonantsensors AT carradam rapidcharacterizationofsolidtumorsusingresonantsensors AT marayatiraoud rapidcharacterizationofsolidtumorsusingresonantsensors AT bowneslaurav rapidcharacterizationofsolidtumorsusingresonantsensors AT hutchinssaraclaire rapidcharacterizationofsolidtumorsusingresonantsensors AT stewartjerrye rapidcharacterizationofsolidtumorsusingresonantsensors AT hillbenjamin rapidcharacterizationofsolidtumorsusingresonantsensors AT ohlmeyermichael rapidcharacterizationofsolidtumorsusingresonantsensors AT reuelnigelf rapidcharacterizationofsolidtumorsusingresonantsensors AT beierleelizabetha rapidcharacterizationofsolidtumorsusingresonantsensors |