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Ag@TiO(2) Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation

[Image: see text] In the present study, a new series of different heterocycles was synthesized through base-free Knoevenagel condensation of various aldehydes and active methylene-containing compounds using the hydrothermal developed Ag@TiO(2) as a heterogeneous catalyst. The catalyst was synthesize...

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Autores principales: Sayed, Mostafa, Shi, Zhipeng, Gholami, Farzad, Fatehi, Pedram, Soliman, Ahmed I. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476541/
https://www.ncbi.nlm.nih.gov/pubmed/36120061
http://dx.doi.org/10.1021/acsomega.2c03852
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author Sayed, Mostafa
Shi, Zhipeng
Gholami, Farzad
Fatehi, Pedram
Soliman, Ahmed I. A.
author_facet Sayed, Mostafa
Shi, Zhipeng
Gholami, Farzad
Fatehi, Pedram
Soliman, Ahmed I. A.
author_sort Sayed, Mostafa
collection PubMed
description [Image: see text] In the present study, a new series of different heterocycles was synthesized through base-free Knoevenagel condensation of various aldehydes and active methylene-containing compounds using the hydrothermal developed Ag@TiO(2) as a heterogeneous catalyst. The catalyst was synthesized by mixing TiO(2) (P25) with AgNO(3) and hydrothermally treated in ethanol at 180 °C for 12 h. The developed Ag@TiO(2) catalyst was directly applied for Knoevenagel condensation, and the optimized procedure involved stirring the aldehydes and active methylene-containing compounds with Ag@TiO(2) in ethanol at 65 °C. The reaction scope was investigated for various aromatic and heterocyclic aldehydes with active methylene-containing compounds, and the isolated yields were significantly high. The reusability of the catalyst was investigated for up to five cycles, where an insignificant decrease in the catalyst’s reactivity was observed. Also, the reaction could proceed in water as a solvent, and the isolated yield was 40%. Hence, this protocol features mild reaction conditions, a facile procedure, and clean reaction profiles.
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spelling pubmed-94765412022-09-16 Ag@TiO(2) Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation Sayed, Mostafa Shi, Zhipeng Gholami, Farzad Fatehi, Pedram Soliman, Ahmed I. A. ACS Omega [Image: see text] In the present study, a new series of different heterocycles was synthesized through base-free Knoevenagel condensation of various aldehydes and active methylene-containing compounds using the hydrothermal developed Ag@TiO(2) as a heterogeneous catalyst. The catalyst was synthesized by mixing TiO(2) (P25) with AgNO(3) and hydrothermally treated in ethanol at 180 °C for 12 h. The developed Ag@TiO(2) catalyst was directly applied for Knoevenagel condensation, and the optimized procedure involved stirring the aldehydes and active methylene-containing compounds with Ag@TiO(2) in ethanol at 65 °C. The reaction scope was investigated for various aromatic and heterocyclic aldehydes with active methylene-containing compounds, and the isolated yields were significantly high. The reusability of the catalyst was investigated for up to five cycles, where an insignificant decrease in the catalyst’s reactivity was observed. Also, the reaction could proceed in water as a solvent, and the isolated yield was 40%. Hence, this protocol features mild reaction conditions, a facile procedure, and clean reaction profiles. American Chemical Society 2022-09-01 /pmc/articles/PMC9476541/ /pubmed/36120061 http://dx.doi.org/10.1021/acsomega.2c03852 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Sayed, Mostafa
Shi, Zhipeng
Gholami, Farzad
Fatehi, Pedram
Soliman, Ahmed I. A.
Ag@TiO(2) Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation
title Ag@TiO(2) Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation
title_full Ag@TiO(2) Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation
title_fullStr Ag@TiO(2) Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation
title_full_unstemmed Ag@TiO(2) Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation
title_short Ag@TiO(2) Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation
title_sort ag@tio(2) nanocomposite as an efficient catalyst for knoevenagel condensation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476541/
https://www.ncbi.nlm.nih.gov/pubmed/36120061
http://dx.doi.org/10.1021/acsomega.2c03852
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