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Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort
BACKGROUND: Sleep disorders are common in Parkinson's disease (PD). However, the longitudinal relationship between sleep quality and the other non-motor symptoms of PD has not been well characterized, especially in early PD. OBJECTIVE: To explore the value of baseline sleep quality in predictin...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476542/ https://www.ncbi.nlm.nih.gov/pubmed/36119701 http://dx.doi.org/10.3389/fneur.2022.998103 |
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author | Koh, Matthew Rui En Chua, Cong Yang Ng, Samuel Yong-Ern Chia, Nicole Shuang-Yu Saffari, Seyed Ehsan Chen, Regina Yu-Ying Choi, Xinyi Heng, Dede Liana Neo, Shermyn Xiumin Tay, Kay Yaw Au, Wing Lok Tan, Eng-King Tan, Louis Chew-Seng Xu, Zheyu |
author_facet | Koh, Matthew Rui En Chua, Cong Yang Ng, Samuel Yong-Ern Chia, Nicole Shuang-Yu Saffari, Seyed Ehsan Chen, Regina Yu-Ying Choi, Xinyi Heng, Dede Liana Neo, Shermyn Xiumin Tay, Kay Yaw Au, Wing Lok Tan, Eng-King Tan, Louis Chew-Seng Xu, Zheyu |
author_sort | Koh, Matthew Rui En |
collection | PubMed |
description | BACKGROUND: Sleep disorders are common in Parkinson's disease (PD). However, the longitudinal relationship between sleep quality and the other non-motor symptoms of PD has not been well characterized, especially in early PD. OBJECTIVE: To explore the value of baseline sleep quality in predicting the progression of other non-motor symptoms in early PD. METHODS: 109 early PD patients were recruited to the study. Patients were stratified into good and poor sleepers using the Pittsburgh Sleep Quality Index (PSQI). Assessments performed at baseline and 1 year follow-up included the Epworth Sleepiness Scale, Fatigue Severity Scale, Non-Motor Symptom Scale, Geriatric Depression Scale, Hospital Anxiety and Depression Scale, Apathy Scale, Montreal Cognitive Assessment and detailed neuropsychological assessments. Multivariable linear regression was performed at baseline to investigate differences in clinical scores between poor and good sleepers, while multivariable regression models were used to investigate associations between sleep quality and progression of test scores at 1 year follow-up. RESULTS: 59 poor sleepers and 50 good sleepers were identified. At baseline, poor sleepers had greater HADS anxiety scores (p = 0.013) [2.99 (95% CI 2.26, 3.73)] than good sleepers [1.59 (95% CI 0.75, 2.42)]. After 1 year, poor sleepers had greater fatigue (FSS scores +3.60 as compared to −2.93 in good sleepers, p = 0.007) and depression (GDS scores +0.42 as compared to −0.70, p = 0.006). CONCLUSION: This study shows a longitudinal association between sleep quality, fatigue, and depression in early PD patients, independent of medication effect and disease severity, this may support the hypothesis that a common serotonergic pathway is implicated in these non-motor symptoms. |
format | Online Article Text |
id | pubmed-9476542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94765422022-09-16 Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort Koh, Matthew Rui En Chua, Cong Yang Ng, Samuel Yong-Ern Chia, Nicole Shuang-Yu Saffari, Seyed Ehsan Chen, Regina Yu-Ying Choi, Xinyi Heng, Dede Liana Neo, Shermyn Xiumin Tay, Kay Yaw Au, Wing Lok Tan, Eng-King Tan, Louis Chew-Seng Xu, Zheyu Front Neurol Neurology BACKGROUND: Sleep disorders are common in Parkinson's disease (PD). However, the longitudinal relationship between sleep quality and the other non-motor symptoms of PD has not been well characterized, especially in early PD. OBJECTIVE: To explore the value of baseline sleep quality in predicting the progression of other non-motor symptoms in early PD. METHODS: 109 early PD patients were recruited to the study. Patients were stratified into good and poor sleepers using the Pittsburgh Sleep Quality Index (PSQI). Assessments performed at baseline and 1 year follow-up included the Epworth Sleepiness Scale, Fatigue Severity Scale, Non-Motor Symptom Scale, Geriatric Depression Scale, Hospital Anxiety and Depression Scale, Apathy Scale, Montreal Cognitive Assessment and detailed neuropsychological assessments. Multivariable linear regression was performed at baseline to investigate differences in clinical scores between poor and good sleepers, while multivariable regression models were used to investigate associations between sleep quality and progression of test scores at 1 year follow-up. RESULTS: 59 poor sleepers and 50 good sleepers were identified. At baseline, poor sleepers had greater HADS anxiety scores (p = 0.013) [2.99 (95% CI 2.26, 3.73)] than good sleepers [1.59 (95% CI 0.75, 2.42)]. After 1 year, poor sleepers had greater fatigue (FSS scores +3.60 as compared to −2.93 in good sleepers, p = 0.007) and depression (GDS scores +0.42 as compared to −0.70, p = 0.006). CONCLUSION: This study shows a longitudinal association between sleep quality, fatigue, and depression in early PD patients, independent of medication effect and disease severity, this may support the hypothesis that a common serotonergic pathway is implicated in these non-motor symptoms. Frontiers Media S.A. 2022-09-01 /pmc/articles/PMC9476542/ /pubmed/36119701 http://dx.doi.org/10.3389/fneur.2022.998103 Text en Copyright © 2022 Koh, Chua, Ng, Chia, Saffari, Chen, Choi, Heng, Neo, Tay, Au, Tan, Tan and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Koh, Matthew Rui En Chua, Cong Yang Ng, Samuel Yong-Ern Chia, Nicole Shuang-Yu Saffari, Seyed Ehsan Chen, Regina Yu-Ying Choi, Xinyi Heng, Dede Liana Neo, Shermyn Xiumin Tay, Kay Yaw Au, Wing Lok Tan, Eng-King Tan, Louis Chew-Seng Xu, Zheyu Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort |
title | Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort |
title_full | Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort |
title_fullStr | Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort |
title_full_unstemmed | Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort |
title_short | Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort |
title_sort | poor sleep quality is associated with fatigue and depression in early parkinson's disease: a longitudinal study in the pals cohort |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476542/ https://www.ncbi.nlm.nih.gov/pubmed/36119701 http://dx.doi.org/10.3389/fneur.2022.998103 |
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