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Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial
BACKGROUND: Late-life depression (LLD) affects up to 18% of older adults and has been linked to elevated dementia risk. Mindfulness-based cognitive therapy (MBCT) holds promise for treating symptoms of depression and ameliorating cognitive deficits in older adults. While preliminary findings are pro...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476649/ https://www.ncbi.nlm.nih.gov/pubmed/36118690 http://dx.doi.org/10.3389/fnagi.2022.976636 |
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author | Bein, Magnus Lesage, Myriam Dikaios, Elena Chakravarty, Mallar Segal, Zindel Royal, Isabelle Speechley, Mark Schiavetto, Alessandra Blumberger, Daniel Sacchet, Matthew D. Therriault, Joseph Gruber, Johanna Tourjman, Valerie Richard-Devantoy, Stephane Nair, Vasavan Bruneau, Marie-Andrée Rej, Soham Lifshitz, Michael Sekhon, Harmehr |
author_facet | Bein, Magnus Lesage, Myriam Dikaios, Elena Chakravarty, Mallar Segal, Zindel Royal, Isabelle Speechley, Mark Schiavetto, Alessandra Blumberger, Daniel Sacchet, Matthew D. Therriault, Joseph Gruber, Johanna Tourjman, Valerie Richard-Devantoy, Stephane Nair, Vasavan Bruneau, Marie-Andrée Rej, Soham Lifshitz, Michael Sekhon, Harmehr |
author_sort | Bein, Magnus |
collection | PubMed |
description | BACKGROUND: Late-life depression (LLD) affects up to 18% of older adults and has been linked to elevated dementia risk. Mindfulness-based cognitive therapy (MBCT) holds promise for treating symptoms of depression and ameliorating cognitive deficits in older adults. While preliminary findings are promising, a definitive RCT investigating its effects on late life depression and cognition have not yet been conducted. We present a protocol describing a multi-site blinded randomized controlled trial, comparing the effects of MBCT and of an active control, a Health Enhancement Program (HEP), on depressive symptoms, executive functioning, and brain biomarkers of LLD, among several other exploratory outcomes. METHODS: Two-hundred and thirteen (n = 213) patients with LLD will be recruited at various centers in Montreal, QC, Canada. Participants will undergo stratified randomization to either MBCT or HEP intervention groups. We will assess changes in (1) depression severity using the Hamilton Depression Rating Scale (HAM-D17), (2) processing speed and executive functioning, (3) brain biomarkers of LLD (hippocampal volume, default network resting-state functional connectivity and executive network resting-state functional connectivity), and (4) other exploratory physiological and mood-based measures, at baseline (0 weeks), post intervention (8 weeks), and 26 weeks after baseline. DISCUSSION: The proposed study will assess the clinical potential of MBCT to improve symptoms of depression, as well as examine its impact on cognitive impairments and neurobiological markers, and thus inform its use as a promising adjunct in the treatment of LLD. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier: NCT05366088. |
format | Online Article Text |
id | pubmed-9476649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94766492022-09-16 Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial Bein, Magnus Lesage, Myriam Dikaios, Elena Chakravarty, Mallar Segal, Zindel Royal, Isabelle Speechley, Mark Schiavetto, Alessandra Blumberger, Daniel Sacchet, Matthew D. Therriault, Joseph Gruber, Johanna Tourjman, Valerie Richard-Devantoy, Stephane Nair, Vasavan Bruneau, Marie-Andrée Rej, Soham Lifshitz, Michael Sekhon, Harmehr Front Aging Neurosci Aging Neuroscience BACKGROUND: Late-life depression (LLD) affects up to 18% of older adults and has been linked to elevated dementia risk. Mindfulness-based cognitive therapy (MBCT) holds promise for treating symptoms of depression and ameliorating cognitive deficits in older adults. While preliminary findings are promising, a definitive RCT investigating its effects on late life depression and cognition have not yet been conducted. We present a protocol describing a multi-site blinded randomized controlled trial, comparing the effects of MBCT and of an active control, a Health Enhancement Program (HEP), on depressive symptoms, executive functioning, and brain biomarkers of LLD, among several other exploratory outcomes. METHODS: Two-hundred and thirteen (n = 213) patients with LLD will be recruited at various centers in Montreal, QC, Canada. Participants will undergo stratified randomization to either MBCT or HEP intervention groups. We will assess changes in (1) depression severity using the Hamilton Depression Rating Scale (HAM-D17), (2) processing speed and executive functioning, (3) brain biomarkers of LLD (hippocampal volume, default network resting-state functional connectivity and executive network resting-state functional connectivity), and (4) other exploratory physiological and mood-based measures, at baseline (0 weeks), post intervention (8 weeks), and 26 weeks after baseline. DISCUSSION: The proposed study will assess the clinical potential of MBCT to improve symptoms of depression, as well as examine its impact on cognitive impairments and neurobiological markers, and thus inform its use as a promising adjunct in the treatment of LLD. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier: NCT05366088. Frontiers Media S.A. 2022-09-01 /pmc/articles/PMC9476649/ /pubmed/36118690 http://dx.doi.org/10.3389/fnagi.2022.976636 Text en Copyright © 2022 Bein, Lesage, Dikaios, Chakravarty, Segal, Royal, Speechley, Schiavetto, Blumberger, Sacchet, Therriault, Gruber, Tourjman, Richard-Devantoy, Nair, Bruneau, Rej, Lifshitz and Sekhon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Bein, Magnus Lesage, Myriam Dikaios, Elena Chakravarty, Mallar Segal, Zindel Royal, Isabelle Speechley, Mark Schiavetto, Alessandra Blumberger, Daniel Sacchet, Matthew D. Therriault, Joseph Gruber, Johanna Tourjman, Valerie Richard-Devantoy, Stephane Nair, Vasavan Bruneau, Marie-Andrée Rej, Soham Lifshitz, Michael Sekhon, Harmehr Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
title | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
title_full | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
title_fullStr | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
title_full_unstemmed | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
title_short | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
title_sort | mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: study protocol for a multi-site randomized controlled trial |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476649/ https://www.ncbi.nlm.nih.gov/pubmed/36118690 http://dx.doi.org/10.3389/fnagi.2022.976636 |
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