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Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea

OBJECTIVE: Clitoria ternatea is a well-known bioactive plant used to treat several inflammatory ailments in Ayurvedic system of medicine in India. The present investigation aimed to determine the anti-inflammatory and anti-arthritic activity of ethanolic extract of Clitoria ternatea roots (EECT) in...

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Autores principales: Swathi, K.P., Jayaram, Saravanan, Sugumar, Deepa, Rymbai, Emdormi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476680/
https://www.ncbi.nlm.nih.gov/pubmed/36117501
http://dx.doi.org/10.1016/j.chmed.2020.11.004
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author Swathi, K.P.
Jayaram, Saravanan
Sugumar, Deepa
Rymbai, Emdormi
author_facet Swathi, K.P.
Jayaram, Saravanan
Sugumar, Deepa
Rymbai, Emdormi
author_sort Swathi, K.P.
collection PubMed
description OBJECTIVE: Clitoria ternatea is a well-known bioactive plant used to treat several inflammatory ailments in Ayurvedic system of medicine in India. The present investigation aimed to determine the anti-inflammatory and anti-arthritic activity of ethanolic extract of Clitoria ternatea roots (EECT) in animal models. METHODS: The anti-inflammatory activity of the EECT was evaluated by carrageenan and histamine-induced paw edema. RESULTS: EECT showed a significant reduction in mean paw edema volume in both carrageenan and histamine-induced inflammation. The efficacy of EECT in rheumatoid arthritis was tested against Freund’s complete adjuvant (CFA) induced arthritic model in Wistar rats. The anti-arthritic effect of EECT was determined by systematic scoring of arthritis symptoms and measuring paw edema. A considerable decrease in paw diameter was observed in the EECT (200 and 400 mg/kg) and diclofenac (10 mg/kg) treated groups after day 7. Diclofenac (10 mg/kg) and EECT (400 mg/kg) showed a significant reduction in paw diameter from day 14 compared with CFA control (P < 0.001). The anti-arthritic activity was also confirmed from the altered biochemical, haematological (Hb, RBC and WBC) and anti-oxidant parameters (SOD, MDA, CAT, and GSH). EECT (400 and 200 mg/kg) also showed a marked inhibition of joint destruction. CONCLUSION: This study provides a pharmacological rationale for the traditional use of C. ternatea against inflammation and rheumatoid arthritis in India.
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spelling pubmed-94766802022-09-16 Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea Swathi, K.P. Jayaram, Saravanan Sugumar, Deepa Rymbai, Emdormi Chin Herb Med Original Article OBJECTIVE: Clitoria ternatea is a well-known bioactive plant used to treat several inflammatory ailments in Ayurvedic system of medicine in India. The present investigation aimed to determine the anti-inflammatory and anti-arthritic activity of ethanolic extract of Clitoria ternatea roots (EECT) in animal models. METHODS: The anti-inflammatory activity of the EECT was evaluated by carrageenan and histamine-induced paw edema. RESULTS: EECT showed a significant reduction in mean paw edema volume in both carrageenan and histamine-induced inflammation. The efficacy of EECT in rheumatoid arthritis was tested against Freund’s complete adjuvant (CFA) induced arthritic model in Wistar rats. The anti-arthritic effect of EECT was determined by systematic scoring of arthritis symptoms and measuring paw edema. A considerable decrease in paw diameter was observed in the EECT (200 and 400 mg/kg) and diclofenac (10 mg/kg) treated groups after day 7. Diclofenac (10 mg/kg) and EECT (400 mg/kg) showed a significant reduction in paw diameter from day 14 compared with CFA control (P < 0.001). The anti-arthritic activity was also confirmed from the altered biochemical, haematological (Hb, RBC and WBC) and anti-oxidant parameters (SOD, MDA, CAT, and GSH). EECT (400 and 200 mg/kg) also showed a marked inhibition of joint destruction. CONCLUSION: This study provides a pharmacological rationale for the traditional use of C. ternatea against inflammation and rheumatoid arthritis in India. Elsevier 2020-12-01 /pmc/articles/PMC9476680/ /pubmed/36117501 http://dx.doi.org/10.1016/j.chmed.2020.11.004 Text en © 2020 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Swathi, K.P.
Jayaram, Saravanan
Sugumar, Deepa
Rymbai, Emdormi
Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea
title Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea
title_full Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea
title_fullStr Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea
title_full_unstemmed Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea
title_short Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea
title_sort evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of clitoria ternatea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476680/
https://www.ncbi.nlm.nih.gov/pubmed/36117501
http://dx.doi.org/10.1016/j.chmed.2020.11.004
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