Cargando…

RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma

BACKGROUND: Severe hypoxia is a prominent character of pancreatic ductal adenocarcinoma (PDAC) microenvironment. In the process of gemcitabine based chemotherapy, PDAC cells are insulted from replication stresses co-induced by hypoxia and gemcitabine. However, PDAC cells get outstanding abilities to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tu, Qiu, Liu, Xiuyun, Yao, Xiaoqing, Li, Ruixue, Liu, Gaojing, Jiang, Honglv, Li, Kaiqin, Chen, Qiongfang, Huang, Xiaoyan, Chang, Qing, Xu, Guoqiang, Zhu, Hong, Shi, Peng, Zhao, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476698/ https://www.ncbi.nlm.nih.gov/pubmed/36109793 http://dx.doi.org/10.1186/s13046-022-02490-3

Ejemplares similares

RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor Growth
por: Jiang, Xiulin, et al.
Publicado: (2021)

Metnase promotes restart and repair of stalled and collapsed replication forks
por: De Haro, Leyma P., et al.
Publicado: (2010)

MUS81-EME2 Promotes Replication Fork Restart
por: Pepe, Alessandra, et al.
Publicado: (2014)

UV stalled replication forks restart by re-priming in human fibroblasts
por: Elvers, Ingegerd, et al.
Publicado: (2011)

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
por: Pomerantz, Richard T., et al.
Publicado: (2010)

Checkpoint-dependent RNR induction promotes fork restart after replicative stress
por: Morafraile, Esther C., et al.
Publicado: (2015)

DNA2 drives processing and restart of reversed replication forks in human cells
por: Thangavel, Saravanabhavan, et al.
Publicado: (2015)

Degradation of Mrc1 promotes recombination-mediated restart of stalled replication forks
por: Chaudhury, Indrajit, et al.
Publicado: (2017)

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
por: Berti, Matteo, et al.
Publicado: (2020)

Restarted replication forks are error-prone and cause CAG repeat expansions and contractions
por: Gold, Michaela A., et al.
Publicado: (2021)

Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells
por: Batenburg, Nicole L, et al.
Publicado: (2021)

Polymerase δ replicates both strands after homologous recombination-dependent fork restart
por: Miyabe, Izumi, et al.
Publicado: (2015)

RIF1 promotes replication fork protection and efficient restart to maintain genome stability
por: Mukherjee, Chirantani, et al.
Publicado: (2019)

METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation
por: Lin, Chengjie, et al.
Publicado: (2023)

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
por: Berti, Matteo, et al.
Publicado: (2013)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2015)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2020)

Correction: METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation
por: Lin, Chengjie, et al.
Publicado: (2023)

Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse
por: Nguyen, Michael O, et al.
Publicado: (2015)

SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms
por: Pedersen, Ida Benedikte, et al.
Publicado: (2017)

DNA Helicase-SSB Interactions Critical to the Regression and Restart of Stalled DNA Replication Forks in Escherichia coli
por: Bianco, Piero R.
Publicado: (2020)

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
por: Shorrocks, Ann-Marie K., et al.
Publicado: (2021)

DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway
por: Zhang, Tong, et al.
Publicado: (2018)

MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart
por: Thakur, Varsha, et al.
Publicado: (2021)

Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway
por: Calì, Federica, et al.
Publicado: (2016)

DDX39B contributes to the proliferation of colorectal cancer through direct binding to CDK6/CCND1
por: Zhang, Haonan, et al.
Publicado: (2022)

Motif WFYY of human PrimPol is crucial to stabilize the incoming 3′-nucleotide during replication fork restart
por: Calvo, Patricia A, et al.
Publicado: (2021)

DDX39 Overexpression Predicts a Poor Prognosis and Promotes Aggressiveness of Melanoma by Cooperating With SNAIL
por: Xing, Chengjuan, et al.
Publicado: (2020)

Case Report: Exome sequencing reveals recurrent RETSAT mutations and a loss-of-function POLDIP2 mutation in a rare undifferentiated tongue sarcoma
por: Chan, Jason Y. K., et al.
Publicado: (2018)

DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2
por: Zhao, Gang, et al.
Publicado: (2022)

Identification and functional analysis of novel oncogene DDX60L in pancreatic ductal adenocarcinoma
por: Wu, Hongjin, et al.
Publicado: (2021)

The Clinical and Pathological Significance of Nectin-2 and DDX3 Expression in Pancreatic Ductal Adenocarcinomas
por: Liang, Shan, et al.
Publicado: (2015)

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
por: Eckelmann, Bradley J, et al.
Publicado: (2020)

Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli
por: Duckworth, Alexander T., et al.
Publicado: (2023)

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart
por: Zhang, Qianting, et al.
Publicado: (2023)

SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stress
por: Zhu, Qian, et al.
Publicado: (2021)

The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer
por: He, Chengcheng, et al.
Publicado: (2021)

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
por: Petermann, Eva, et al.
Publicado: (2010)

Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly
por: Xie, Yihu, et al.
Publicado: (2023)

Real-world outcomes of adjuvant gemcitabine versus gemcitabine plus capecitabine for resected pancreatic ductal adenocarcinoma
por: Kang, Sora, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ddlij2av60dh2q70bb2bf28d5j