Cargando…

Analgesic alkaloids from Urticae Fissae Herba

OBJECTIVE: To investigate the analgesic substances in the aerial part of Urtica fissa (Urticae Fissae Herba), commonly used for rheumatoid and rheumatism arthritis. METHODS: The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models, and identified...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Xiaoru, Ju, Peijun, Chen, Yan, Li, Xiaobo, Wang, Mengyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476718/
https://www.ncbi.nlm.nih.gov/pubmed/36120129
http://dx.doi.org/10.1016/j.chmed.2021.09.008
_version_ 1784790200045535232
author Feng, Xiaoru
Ju, Peijun
Chen, Yan
Li, Xiaobo
Wang, Mengyue
author_facet Feng, Xiaoru
Ju, Peijun
Chen, Yan
Li, Xiaobo
Wang, Mengyue
author_sort Feng, Xiaoru
collection PubMed
description OBJECTIVE: To investigate the analgesic substances in the aerial part of Urtica fissa (Urticae Fissae Herba), commonly used for rheumatoid and rheumatism arthritis. METHODS: The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models, and identified by comprehensive spectroscopic analysis. RESULTS: Thirteen alkaloids (1–13), two lignans (14, 15), and three amides (16–18) were isolated from the active fractions. Among them, compound 1 was a new alkaloid, and compound 6 was a new natural product. The activity evaluation in vivo indicated that various pyrrole alkaloids (1, 3, 6, and 12) possessed significant analgesic activities, they could significantly inhibit the mice pain response induced by acetic acid and hot plate at the dosage of 2 mg/kg BW. CONCLUSION: The study revealed that the pyrrole alkaloids played important roles in the analgesic activities of Urticae Fissae Herba.
format Online
Article
Text
id pubmed-9476718
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-94767182022-09-16 Analgesic alkaloids from Urticae Fissae Herba Feng, Xiaoru Ju, Peijun Chen, Yan Li, Xiaobo Wang, Mengyue Chin Herb Med Original Article OBJECTIVE: To investigate the analgesic substances in the aerial part of Urtica fissa (Urticae Fissae Herba), commonly used for rheumatoid and rheumatism arthritis. METHODS: The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models, and identified by comprehensive spectroscopic analysis. RESULTS: Thirteen alkaloids (1–13), two lignans (14, 15), and three amides (16–18) were isolated from the active fractions. Among them, compound 1 was a new alkaloid, and compound 6 was a new natural product. The activity evaluation in vivo indicated that various pyrrole alkaloids (1, 3, 6, and 12) possessed significant analgesic activities, they could significantly inhibit the mice pain response induced by acetic acid and hot plate at the dosage of 2 mg/kg BW. CONCLUSION: The study revealed that the pyrrole alkaloids played important roles in the analgesic activities of Urticae Fissae Herba. Elsevier 2021-09-23 /pmc/articles/PMC9476718/ /pubmed/36120129 http://dx.doi.org/10.1016/j.chmed.2021.09.008 Text en © 2021 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Feng, Xiaoru
Ju, Peijun
Chen, Yan
Li, Xiaobo
Wang, Mengyue
Analgesic alkaloids from Urticae Fissae Herba
title Analgesic alkaloids from Urticae Fissae Herba
title_full Analgesic alkaloids from Urticae Fissae Herba
title_fullStr Analgesic alkaloids from Urticae Fissae Herba
title_full_unstemmed Analgesic alkaloids from Urticae Fissae Herba
title_short Analgesic alkaloids from Urticae Fissae Herba
title_sort analgesic alkaloids from urticae fissae herba
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476718/
https://www.ncbi.nlm.nih.gov/pubmed/36120129
http://dx.doi.org/10.1016/j.chmed.2021.09.008
work_keys_str_mv AT fengxiaoru analgesicalkaloidsfromurticaefissaeherba
AT jupeijun analgesicalkaloidsfromurticaefissaeherba
AT chenyan analgesicalkaloidsfromurticaefissaeherba
AT lixiaobo analgesicalkaloidsfromurticaefissaeherba
AT wangmengyue analgesicalkaloidsfromurticaefissaeherba