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A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars

OBJECTIVE: To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition (SCMC) ointment on the rabbit ear hypertrophic scar models. METHODS: The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests. The SCMC oi...

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Autores principales: Wang, Zu-hua, Sun, Xue-yan, Zhang, Jiao-jiao, Giampieri, Francesca, Jiang, Cheng-ju, Feng, Ting-ting, Wang, Zhi-wei, Chen, Rong-yi, Battino, Maurizio, Zhou, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476741/
https://www.ncbi.nlm.nih.gov/pubmed/36117509
http://dx.doi.org/10.1016/j.chmed.2020.12.007
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author Wang, Zu-hua
Sun, Xue-yan
Zhang, Jiao-jiao
Giampieri, Francesca
Jiang, Cheng-ju
Feng, Ting-ting
Wang, Zhi-wei
Chen, Rong-yi
Battino, Maurizio
Zhou, Ying
author_facet Wang, Zu-hua
Sun, Xue-yan
Zhang, Jiao-jiao
Giampieri, Francesca
Jiang, Cheng-ju
Feng, Ting-ting
Wang, Zhi-wei
Chen, Rong-yi
Battino, Maurizio
Zhou, Ying
author_sort Wang, Zu-hua
collection PubMed
description OBJECTIVE: To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition (SCMC) ointment on the rabbit ear hypertrophic scar models. METHODS: The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests. The SCMC ointment was prepared through emulsifying method. The rabbit ear hypertrophic scar models were established and used to investigate the anti-hypertrophic scar effect of SCMC ointment. RESULTS: Our results demonstrated that all the quality control indications of the SCMC ointment met the requirements. Anti-hypertrophic scar activity results showed that all the rabbit ear scar tissues appeared different degrees of shrink and fading, and took an unobvious but palpable shift from hard to soft texture with the low, middle and high concentration SCMC ointments treatments in vivo. Additionally, on 21st day the scar area and thickness in different concentrations of SCMC ointment groups were significantly reduced than control group, in a concentration-dependent manner. The immunohistochemical results also indicated that the SCMC ointment had good anti-hypertrophic scar properties and could inhibit hypertrophic scar formation. CONCLUSION: The SCMC ointment could improve the blood circulation condition of hypertrophic scar tissues. Our research has demonstrated the Chinese medicine composition ointment with good anti-hypertrophic scar properties that could be used to treat hypertrophic scars. Meanwhile, it provides a theoretical basis for further clinical application.
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spelling pubmed-94767412022-09-16 A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars Wang, Zu-hua Sun, Xue-yan Zhang, Jiao-jiao Giampieri, Francesca Jiang, Cheng-ju Feng, Ting-ting Wang, Zhi-wei Chen, Rong-yi Battino, Maurizio Zhou, Ying Chin Herb Med Original Article OBJECTIVE: To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition (SCMC) ointment on the rabbit ear hypertrophic scar models. METHODS: The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests. The SCMC ointment was prepared through emulsifying method. The rabbit ear hypertrophic scar models were established and used to investigate the anti-hypertrophic scar effect of SCMC ointment. RESULTS: Our results demonstrated that all the quality control indications of the SCMC ointment met the requirements. Anti-hypertrophic scar activity results showed that all the rabbit ear scar tissues appeared different degrees of shrink and fading, and took an unobvious but palpable shift from hard to soft texture with the low, middle and high concentration SCMC ointments treatments in vivo. Additionally, on 21st day the scar area and thickness in different concentrations of SCMC ointment groups were significantly reduced than control group, in a concentration-dependent manner. The immunohistochemical results also indicated that the SCMC ointment had good anti-hypertrophic scar properties and could inhibit hypertrophic scar formation. CONCLUSION: The SCMC ointment could improve the blood circulation condition of hypertrophic scar tissues. Our research has demonstrated the Chinese medicine composition ointment with good anti-hypertrophic scar properties that could be used to treat hypertrophic scars. Meanwhile, it provides a theoretical basis for further clinical application. Elsevier 2020-12-29 /pmc/articles/PMC9476741/ /pubmed/36117509 http://dx.doi.org/10.1016/j.chmed.2020.12.007 Text en © 2020 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Wang, Zu-hua
Sun, Xue-yan
Zhang, Jiao-jiao
Giampieri, Francesca
Jiang, Cheng-ju
Feng, Ting-ting
Wang, Zhi-wei
Chen, Rong-yi
Battino, Maurizio
Zhou, Ying
A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
title A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
title_full A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
title_fullStr A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
title_full_unstemmed A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
title_short A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
title_sort six-herb chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476741/
https://www.ncbi.nlm.nih.gov/pubmed/36117509
http://dx.doi.org/10.1016/j.chmed.2020.12.007
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