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Three new triterpenoid saponins from Aralia echinocaulis
OBJECTIVE: To study the active ingredients in the root bark of Aralia echinocaulis. METHODS: Three triterpenoid saponins were separated from the 70% ethanol extracts and purified by column chromatography and their structures were determined by spectroscopic analysis. Compound 1 and 3 were evaluated...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476764/ https://www.ncbi.nlm.nih.gov/pubmed/36117664 http://dx.doi.org/10.1016/j.chmed.2022.02.002 |
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author | Yan, Mengyun Sun, Yajia Ding, Ling Sun, Jiuxu Song, Jingzhu Zhou, Wenbin Pei, Lingpeng |
author_facet | Yan, Mengyun Sun, Yajia Ding, Ling Sun, Jiuxu Song, Jingzhu Zhou, Wenbin Pei, Lingpeng |
author_sort | Yan, Mengyun |
collection | PubMed |
description | OBJECTIVE: To study the active ingredients in the root bark of Aralia echinocaulis. METHODS: Three triterpenoid saponins were separated from the 70% ethanol extracts and purified by column chromatography and their structures were determined by spectroscopic analysis. Compound 1 and 3 were evaluated for antioxidant activity by the in vitro DPPH free radical scavenging ability and the protective effect of OH(−) induced DNA oxidative damage. RESULTS: Compound 1 was a new type of triterpenoid saponin, named as echinocaulisaglycone 3-O-β-D-glucopyranoside (echinocaulisaponin A), and it had good antioxidant activity. Compound 2 was similar to compound 1, named as 1-hydroxyl-echinocaulisaglycone 3-O-β-D-glucopyranoside (echinocaulisaponin B). Compound 3 was also a new type of triterpenoid saponin, named as echinocaulisaglycone II 3-O-α-L-arabinopyranosyl-(1″→4′)-β-D-glucopyranosiduronic acid (echinocaulisaponin C), and its antioxidant activity was weaker than compound 1. CONCLUSION: In this study, three new compounds were discovered and two of them were carried out in vitro anti-oxidation studies, laying the foundation for further research on the treatment of related diseases (cardiovascular disease, arthritis, age-related macular degeneration, etc.) through anti-oxidation or quenching free radical function. |
format | Online Article Text |
id | pubmed-9476764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94767642022-09-16 Three new triterpenoid saponins from Aralia echinocaulis Yan, Mengyun Sun, Yajia Ding, Ling Sun, Jiuxu Song, Jingzhu Zhou, Wenbin Pei, Lingpeng Chin Herb Med Original Article OBJECTIVE: To study the active ingredients in the root bark of Aralia echinocaulis. METHODS: Three triterpenoid saponins were separated from the 70% ethanol extracts and purified by column chromatography and their structures were determined by spectroscopic analysis. Compound 1 and 3 were evaluated for antioxidant activity by the in vitro DPPH free radical scavenging ability and the protective effect of OH(−) induced DNA oxidative damage. RESULTS: Compound 1 was a new type of triterpenoid saponin, named as echinocaulisaglycone 3-O-β-D-glucopyranoside (echinocaulisaponin A), and it had good antioxidant activity. Compound 2 was similar to compound 1, named as 1-hydroxyl-echinocaulisaglycone 3-O-β-D-glucopyranoside (echinocaulisaponin B). Compound 3 was also a new type of triterpenoid saponin, named as echinocaulisaglycone II 3-O-α-L-arabinopyranosyl-(1″→4′)-β-D-glucopyranosiduronic acid (echinocaulisaponin C), and its antioxidant activity was weaker than compound 1. CONCLUSION: In this study, three new compounds were discovered and two of them were carried out in vitro anti-oxidation studies, laying the foundation for further research on the treatment of related diseases (cardiovascular disease, arthritis, age-related macular degeneration, etc.) through anti-oxidation or quenching free radical function. Elsevier 2022-02-18 /pmc/articles/PMC9476764/ /pubmed/36117664 http://dx.doi.org/10.1016/j.chmed.2022.02.002 Text en © 2022 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Yan, Mengyun Sun, Yajia Ding, Ling Sun, Jiuxu Song, Jingzhu Zhou, Wenbin Pei, Lingpeng Three new triterpenoid saponins from Aralia echinocaulis |
title | Three new triterpenoid saponins from Aralia echinocaulis |
title_full | Three new triterpenoid saponins from Aralia echinocaulis |
title_fullStr | Three new triterpenoid saponins from Aralia echinocaulis |
title_full_unstemmed | Three new triterpenoid saponins from Aralia echinocaulis |
title_short | Three new triterpenoid saponins from Aralia echinocaulis |
title_sort | three new triterpenoid saponins from aralia echinocaulis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476764/ https://www.ncbi.nlm.nih.gov/pubmed/36117664 http://dx.doi.org/10.1016/j.chmed.2022.02.002 |
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