Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome

OBJECTIVE: The current investigation aimed to determine the appropriate dosage form by comparing solid dispersion and liposome to achieve the purpose of improving the solubility and bioavailability of linarin. METHODS: Linarin solid dispersion (LSD) and linarin liposome (LL) were developed via the s...

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Autores principales: Huang, Yingying, Xu, Lihua, Zhang, Fangping, Liu, Yang, Wang, Yunyu, Meng, Fangfeng, Li, Shuang, Cheng, Xintao, Bi, Yuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476784/
https://www.ncbi.nlm.nih.gov/pubmed/36117666
http://dx.doi.org/10.1016/j.chmed.2021.12.004
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author Huang, Yingying
Xu, Lihua
Zhang, Fangping
Liu, Yang
Wang, Yunyu
Meng, Fangfeng
Li, Shuang
Cheng, Xintao
Bi, Yuefeng
author_facet Huang, Yingying
Xu, Lihua
Zhang, Fangping
Liu, Yang
Wang, Yunyu
Meng, Fangfeng
Li, Shuang
Cheng, Xintao
Bi, Yuefeng
author_sort Huang, Yingying
collection PubMed
description OBJECTIVE: The current investigation aimed to determine the appropriate dosage form by comparing solid dispersion and liposome to achieve the purpose of improving the solubility and bioavailability of linarin. METHODS: Linarin solid dispersion (LSD) and linarin liposome (LL) were developed via the solvent method and the thin film hydration method respectively. The Transwell chamber model of Caco-2 cells was established to evaluate the absorption of drug. The pharmacokinetics of linarin, LSD and LL in rats after ig administration were carried out by high performance liquid chromatography (HPLC) method. RESULTS: The solubility of LSD and LL was severally 3.29 times and 3.09 times than that of linarin. The permeation coefficients of LSD and LL were greater than 10(−6), indicating that the absorption of LSD and LL were both better than linarin. The bioavailability of the LSD was 3.363 times higher than that of linarin, and the bioavailability of LL was 0.9886 times higher than that of linarin. CONCLUSION: The linarin was more suitable for making solid dispersion to enhance its solubility and bioavailability.
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spelling pubmed-94767842022-09-16 Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome Huang, Yingying Xu, Lihua Zhang, Fangping Liu, Yang Wang, Yunyu Meng, Fangfeng Li, Shuang Cheng, Xintao Bi, Yuefeng Chin Herb Med Original Article OBJECTIVE: The current investigation aimed to determine the appropriate dosage form by comparing solid dispersion and liposome to achieve the purpose of improving the solubility and bioavailability of linarin. METHODS: Linarin solid dispersion (LSD) and linarin liposome (LL) were developed via the solvent method and the thin film hydration method respectively. The Transwell chamber model of Caco-2 cells was established to evaluate the absorption of drug. The pharmacokinetics of linarin, LSD and LL in rats after ig administration were carried out by high performance liquid chromatography (HPLC) method. RESULTS: The solubility of LSD and LL was severally 3.29 times and 3.09 times than that of linarin. The permeation coefficients of LSD and LL were greater than 10(−6), indicating that the absorption of LSD and LL were both better than linarin. The bioavailability of the LSD was 3.363 times higher than that of linarin, and the bioavailability of LL was 0.9886 times higher than that of linarin. CONCLUSION: The linarin was more suitable for making solid dispersion to enhance its solubility and bioavailability. Elsevier 2022-04-02 /pmc/articles/PMC9476784/ /pubmed/36117666 http://dx.doi.org/10.1016/j.chmed.2021.12.004 Text en © 2022 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Huang, Yingying
Xu, Lihua
Zhang, Fangping
Liu, Yang
Wang, Yunyu
Meng, Fangfeng
Li, Shuang
Cheng, Xintao
Bi, Yuefeng
Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome
title Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome
title_full Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome
title_fullStr Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome
title_full_unstemmed Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome
title_short Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome
title_sort preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476784/
https://www.ncbi.nlm.nih.gov/pubmed/36117666
http://dx.doi.org/10.1016/j.chmed.2021.12.004
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