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Who to screen and how to screen for celiac disease

Celiac disease (CeD) is a chronic gluten-induced enteropathy with plethoric manifestations. The typical manifestations of CeD such as chronic diarrhea and malabsorption are widely recognized, however, many patients have atypical manifestations like iron deficiency anemia, idiopathic short stature, h...

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Autores principales: Singh, Prashant, Singh, Achintya Dinesh, Ahuja, Vineet, Makharia, Govind K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476868/
https://www.ncbi.nlm.nih.gov/pubmed/36157923
http://dx.doi.org/10.3748/wjg.v28.i32.4493
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author Singh, Prashant
Singh, Achintya Dinesh
Ahuja, Vineet
Makharia, Govind K
author_facet Singh, Prashant
Singh, Achintya Dinesh
Ahuja, Vineet
Makharia, Govind K
author_sort Singh, Prashant
collection PubMed
description Celiac disease (CeD) is a chronic gluten-induced enteropathy with plethoric manifestations. The typical manifestations of CeD such as chronic diarrhea and malabsorption are widely recognized, however, many patients have atypical manifestations like iron deficiency anemia, idiopathic short stature, hypertransaminesemia or infertility, etc. These patients often present to the primary care physicians and/or non-gastrointestinal specialties. However, due to a lack of awareness among the healthcare professionals about the various atypical manifestations, many patients are not screened for CeD. In this review, we have summarized the available literature about the prevalence of CeD in various gastrointestinal (chronic diarrhea) and non-gastrointestinal conditions (iron deficiency anemia, short stature, cryptogenic hypertransaminesemia, cryptogenic cirrhosis or idiopathic ataxia etc.) where the diagnosis of CeD should be con-sidered. In addition, we also discuss special scenarios where screening for CeD should be considered even in absence of symptoms such as patients with type 1 diabetes, Down’s syndrome, and first-degree relatives of patients with CeD. Further, we discuss the diagnostic performance and limitations of various screening tests for CeD such as IgA anti-tissue transglutaminase antibodies, anti-endomysial antibodies and anti-deamidated gliadin antibodies. Based on the current recommendations, we propose a diagnostic algorithm for patients with suspected CeD.
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spelling pubmed-94768682022-09-23 Who to screen and how to screen for celiac disease Singh, Prashant Singh, Achintya Dinesh Ahuja, Vineet Makharia, Govind K World J Gastroenterol Minireviews Celiac disease (CeD) is a chronic gluten-induced enteropathy with plethoric manifestations. The typical manifestations of CeD such as chronic diarrhea and malabsorption are widely recognized, however, many patients have atypical manifestations like iron deficiency anemia, idiopathic short stature, hypertransaminesemia or infertility, etc. These patients often present to the primary care physicians and/or non-gastrointestinal specialties. However, due to a lack of awareness among the healthcare professionals about the various atypical manifestations, many patients are not screened for CeD. In this review, we have summarized the available literature about the prevalence of CeD in various gastrointestinal (chronic diarrhea) and non-gastrointestinal conditions (iron deficiency anemia, short stature, cryptogenic hypertransaminesemia, cryptogenic cirrhosis or idiopathic ataxia etc.) where the diagnosis of CeD should be con-sidered. In addition, we also discuss special scenarios where screening for CeD should be considered even in absence of symptoms such as patients with type 1 diabetes, Down’s syndrome, and first-degree relatives of patients with CeD. Further, we discuss the diagnostic performance and limitations of various screening tests for CeD such as IgA anti-tissue transglutaminase antibodies, anti-endomysial antibodies and anti-deamidated gliadin antibodies. Based on the current recommendations, we propose a diagnostic algorithm for patients with suspected CeD. Baishideng Publishing Group Inc 2022-08-28 2022-08-28 /pmc/articles/PMC9476868/ /pubmed/36157923 http://dx.doi.org/10.3748/wjg.v28.i32.4493 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Singh, Prashant
Singh, Achintya Dinesh
Ahuja, Vineet
Makharia, Govind K
Who to screen and how to screen for celiac disease
title Who to screen and how to screen for celiac disease
title_full Who to screen and how to screen for celiac disease
title_fullStr Who to screen and how to screen for celiac disease
title_full_unstemmed Who to screen and how to screen for celiac disease
title_short Who to screen and how to screen for celiac disease
title_sort who to screen and how to screen for celiac disease
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476868/
https://www.ncbi.nlm.nih.gov/pubmed/36157923
http://dx.doi.org/10.3748/wjg.v28.i32.4493
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