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White matter hyperintensities volume and cognition: A meta-analysis

BACKGROUND: Cerebral small vessel disease (CSVD) is prevalent in the elderly and leads to an increased risk of cognitive impairment and dementia. The volume of white matter hyperintensities (WMHs) increases with age, which affects cognition. OBJECTIVE: To explore the relationship between WMH volume...

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Autores principales: Guo, Wenjuan, Shi, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476945/
https://www.ncbi.nlm.nih.gov/pubmed/36118701
http://dx.doi.org/10.3389/fnagi.2022.949763
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author Guo, Wenjuan
Shi, Jing
author_facet Guo, Wenjuan
Shi, Jing
author_sort Guo, Wenjuan
collection PubMed
description BACKGROUND: Cerebral small vessel disease (CSVD) is prevalent in the elderly and leads to an increased risk of cognitive impairment and dementia. The volume of white matter hyperintensities (WMHs) increases with age, which affects cognition. OBJECTIVE: To explore the relationship between WMH volume and cognitive decline in patients with CSVD. METHODS: We performed a systematic search of PubMed, Embase, and the Web of Science databases from their respective creation dates to the 5 May 2022 to identify all the clinical studies on either mild cognitive impairment (MCI) or dementia in regards to WMH volume in CSVD. RESULTS: White matter hyperintensities was associated with the risk of both the MCI and dementia, with a 35% increased risk [relative risk (RR) = 1.35; (95% CI: 1.01–1.81)] of progression from cognitively unimpaired (CU) to MCI (six studies, n = 2,278) and a 49% increased risk [RR = 1.49; (95% CI: 1.21–1.84)] of progression to dementia (six studies, n = 6,330). In a subgroup analysis, a follow-up period of over 5 years increased the risk of MCI by 40% [RR = 1.40; (95% CI: 1.07–1.82)] and dementia by 48% [RR = 1.48; (95% CI: 1.15–1.92)]. CONCLUSION: White matter hyperintensities was found to be substantially correlated with the risk of cognitive impairment. Furthermore, cognitive decline was found to be a chronic process, such that WMH predicted the rate of cognitive decline in CSVD beyond 5 years. The cognitive decline observed in patients with WMH may, therefore, be minimized by early intervention.
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spelling pubmed-94769452022-09-16 White matter hyperintensities volume and cognition: A meta-analysis Guo, Wenjuan Shi, Jing Front Aging Neurosci Aging Neuroscience BACKGROUND: Cerebral small vessel disease (CSVD) is prevalent in the elderly and leads to an increased risk of cognitive impairment and dementia. The volume of white matter hyperintensities (WMHs) increases with age, which affects cognition. OBJECTIVE: To explore the relationship between WMH volume and cognitive decline in patients with CSVD. METHODS: We performed a systematic search of PubMed, Embase, and the Web of Science databases from their respective creation dates to the 5 May 2022 to identify all the clinical studies on either mild cognitive impairment (MCI) or dementia in regards to WMH volume in CSVD. RESULTS: White matter hyperintensities was associated with the risk of both the MCI and dementia, with a 35% increased risk [relative risk (RR) = 1.35; (95% CI: 1.01–1.81)] of progression from cognitively unimpaired (CU) to MCI (six studies, n = 2,278) and a 49% increased risk [RR = 1.49; (95% CI: 1.21–1.84)] of progression to dementia (six studies, n = 6,330). In a subgroup analysis, a follow-up period of over 5 years increased the risk of MCI by 40% [RR = 1.40; (95% CI: 1.07–1.82)] and dementia by 48% [RR = 1.48; (95% CI: 1.15–1.92)]. CONCLUSION: White matter hyperintensities was found to be substantially correlated with the risk of cognitive impairment. Furthermore, cognitive decline was found to be a chronic process, such that WMH predicted the rate of cognitive decline in CSVD beyond 5 years. The cognitive decline observed in patients with WMH may, therefore, be minimized by early intervention. Frontiers Media S.A. 2022-09-01 /pmc/articles/PMC9476945/ /pubmed/36118701 http://dx.doi.org/10.3389/fnagi.2022.949763 Text en Copyright © 2022 Guo and Shi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Guo, Wenjuan
Shi, Jing
White matter hyperintensities volume and cognition: A meta-analysis
title White matter hyperintensities volume and cognition: A meta-analysis
title_full White matter hyperintensities volume and cognition: A meta-analysis
title_fullStr White matter hyperintensities volume and cognition: A meta-analysis
title_full_unstemmed White matter hyperintensities volume and cognition: A meta-analysis
title_short White matter hyperintensities volume and cognition: A meta-analysis
title_sort white matter hyperintensities volume and cognition: a meta-analysis
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476945/
https://www.ncbi.nlm.nih.gov/pubmed/36118701
http://dx.doi.org/10.3389/fnagi.2022.949763
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