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Ratiometric rapid distinction of two structurally similar fluoroquinolone antibiotics by a Tb/Eu hydrogel
Norfloxacin and ofloxacin are two frequently prescribed second-generation fluoroquinolone antibiotics with an identical 4-quinolone chromophore and hence, are difficult to distinguish by conventional methods (UV or fluorescence). We have designed a Tb(3+)/Eu(3+)/cholate cocktail that enabled us to d...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477015/ https://www.ncbi.nlm.nih.gov/pubmed/36275113 http://dx.doi.org/10.1039/d2ra03668a |
Sumario: | Norfloxacin and ofloxacin are two frequently prescribed second-generation fluoroquinolone antibiotics with an identical 4-quinolone chromophore and hence, are difficult to distinguish by conventional methods (UV or fluorescence). We have designed a Tb(3+)/Eu(3+)/cholate cocktail that enabled us to differentiate these two drugs and rapidly measure their concentrations when present together. Additionally, a Tb(3+)-cholate gel-based paper sensor was developed to detect and quantify them in a single drug containing system with a limit of detection (LOD) well below 100 nM. |
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