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Multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-Wittig/Diels–Alder sequence
A three-component synthesis of polysubstituted pyridines has been developed, based upon the synthesis of 2-azadienes by a redox-neutral catalytic intermolecular aza-Wittig reaction and their subsequent Diels–Alder reactions. The two-pot process has been demonstrated using a range of aryl and heteroa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477066/ https://www.ncbi.nlm.nih.gov/pubmed/36275096 http://dx.doi.org/10.1039/d2ra05018h |
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author | Bayana, Mary E. Wailes, J. Steven Marsden, Stephen P. |
author_facet | Bayana, Mary E. Wailes, J. Steven Marsden, Stephen P. |
author_sort | Bayana, Mary E. |
collection | PubMed |
description | A three-component synthesis of polysubstituted pyridines has been developed, based upon the synthesis of 2-azadienes by a redox-neutral catalytic intermolecular aza-Wittig reaction and their subsequent Diels–Alder reactions. The two-pot process has been demonstrated using a range of aryl and heteroaromatic aldehydes, substituted α,β-unsaturated acids and push–pull enamines, to give rapid access to diverse tri- and tetrasubstituted pyridines. |
format | Online Article Text |
id | pubmed-9477066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-94770662022-10-20 Multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-Wittig/Diels–Alder sequence Bayana, Mary E. Wailes, J. Steven Marsden, Stephen P. RSC Adv Chemistry A three-component synthesis of polysubstituted pyridines has been developed, based upon the synthesis of 2-azadienes by a redox-neutral catalytic intermolecular aza-Wittig reaction and their subsequent Diels–Alder reactions. The two-pot process has been demonstrated using a range of aryl and heteroaromatic aldehydes, substituted α,β-unsaturated acids and push–pull enamines, to give rapid access to diverse tri- and tetrasubstituted pyridines. The Royal Society of Chemistry 2022-09-15 /pmc/articles/PMC9477066/ /pubmed/36275096 http://dx.doi.org/10.1039/d2ra05018h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Bayana, Mary E. Wailes, J. Steven Marsden, Stephen P. Multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-Wittig/Diels–Alder sequence |
title | Multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-Wittig/Diels–Alder sequence |
title_full | Multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-Wittig/Diels–Alder sequence |
title_fullStr | Multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-Wittig/Diels–Alder sequence |
title_full_unstemmed | Multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-Wittig/Diels–Alder sequence |
title_short | Multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-Wittig/Diels–Alder sequence |
title_sort | multicomponent synthesis of substituted pyridines via a catalytic intermolecular aza-wittig/diels–alder sequence |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477066/ https://www.ncbi.nlm.nih.gov/pubmed/36275096 http://dx.doi.org/10.1039/d2ra05018h |
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