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Advances in understanding red blood cell modifications by Babesia
Babesia are tick-borne protozoan parasites that can infect livestock, pets, wildlife animals, and humans. In the mammalian host, they invade and multiply within red blood cells (RBCs). To support their development as obligate intracellular parasites, Babesia export numerous proteins to modify the RB...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477259/ https://www.ncbi.nlm.nih.gov/pubmed/36107982 http://dx.doi.org/10.1371/journal.ppat.1010770 |
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author | Hakimi, Hassan Yamagishi, Junya Kawazu, Shin-ichiro Asada, Masahito |
author_facet | Hakimi, Hassan Yamagishi, Junya Kawazu, Shin-ichiro Asada, Masahito |
author_sort | Hakimi, Hassan |
collection | PubMed |
description | Babesia are tick-borne protozoan parasites that can infect livestock, pets, wildlife animals, and humans. In the mammalian host, they invade and multiply within red blood cells (RBCs). To support their development as obligate intracellular parasites, Babesia export numerous proteins to modify the RBC during invasion and development. Such exported proteins are likely important for parasite survival and pathogenicity and thus represent candidate drug or vaccine targets. The availability of complete genome sequences and the establishment of transfection systems for several Babesia species have aided the identification and functional characterization of exported proteins. Here, we review exported Babesia proteins; discuss their functions in the context of immune evasion, cytoadhesion, and nutrient uptake; and highlight possible future topics for research and application in this field. |
format | Online Article Text |
id | pubmed-9477259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94772592022-09-16 Advances in understanding red blood cell modifications by Babesia Hakimi, Hassan Yamagishi, Junya Kawazu, Shin-ichiro Asada, Masahito PLoS Pathog Review Babesia are tick-borne protozoan parasites that can infect livestock, pets, wildlife animals, and humans. In the mammalian host, they invade and multiply within red blood cells (RBCs). To support their development as obligate intracellular parasites, Babesia export numerous proteins to modify the RBC during invasion and development. Such exported proteins are likely important for parasite survival and pathogenicity and thus represent candidate drug or vaccine targets. The availability of complete genome sequences and the establishment of transfection systems for several Babesia species have aided the identification and functional characterization of exported proteins. Here, we review exported Babesia proteins; discuss their functions in the context of immune evasion, cytoadhesion, and nutrient uptake; and highlight possible future topics for research and application in this field. Public Library of Science 2022-09-15 /pmc/articles/PMC9477259/ /pubmed/36107982 http://dx.doi.org/10.1371/journal.ppat.1010770 Text en © 2022 Hakimi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Hakimi, Hassan Yamagishi, Junya Kawazu, Shin-ichiro Asada, Masahito Advances in understanding red blood cell modifications by Babesia |
title | Advances in understanding red blood cell modifications by Babesia |
title_full | Advances in understanding red blood cell modifications by Babesia |
title_fullStr | Advances in understanding red blood cell modifications by Babesia |
title_full_unstemmed | Advances in understanding red blood cell modifications by Babesia |
title_short | Advances in understanding red blood cell modifications by Babesia |
title_sort | advances in understanding red blood cell modifications by babesia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477259/ https://www.ncbi.nlm.nih.gov/pubmed/36107982 http://dx.doi.org/10.1371/journal.ppat.1010770 |
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