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Advances in understanding red blood cell modifications by Babesia

Babesia are tick-borne protozoan parasites that can infect livestock, pets, wildlife animals, and humans. In the mammalian host, they invade and multiply within red blood cells (RBCs). To support their development as obligate intracellular parasites, Babesia export numerous proteins to modify the RB...

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Autores principales: Hakimi, Hassan, Yamagishi, Junya, Kawazu, Shin-ichiro, Asada, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477259/
https://www.ncbi.nlm.nih.gov/pubmed/36107982
http://dx.doi.org/10.1371/journal.ppat.1010770
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author Hakimi, Hassan
Yamagishi, Junya
Kawazu, Shin-ichiro
Asada, Masahito
author_facet Hakimi, Hassan
Yamagishi, Junya
Kawazu, Shin-ichiro
Asada, Masahito
author_sort Hakimi, Hassan
collection PubMed
description Babesia are tick-borne protozoan parasites that can infect livestock, pets, wildlife animals, and humans. In the mammalian host, they invade and multiply within red blood cells (RBCs). To support their development as obligate intracellular parasites, Babesia export numerous proteins to modify the RBC during invasion and development. Such exported proteins are likely important for parasite survival and pathogenicity and thus represent candidate drug or vaccine targets. The availability of complete genome sequences and the establishment of transfection systems for several Babesia species have aided the identification and functional characterization of exported proteins. Here, we review exported Babesia proteins; discuss their functions in the context of immune evasion, cytoadhesion, and nutrient uptake; and highlight possible future topics for research and application in this field.
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spelling pubmed-94772592022-09-16 Advances in understanding red blood cell modifications by Babesia Hakimi, Hassan Yamagishi, Junya Kawazu, Shin-ichiro Asada, Masahito PLoS Pathog Review Babesia are tick-borne protozoan parasites that can infect livestock, pets, wildlife animals, and humans. In the mammalian host, they invade and multiply within red blood cells (RBCs). To support their development as obligate intracellular parasites, Babesia export numerous proteins to modify the RBC during invasion and development. Such exported proteins are likely important for parasite survival and pathogenicity and thus represent candidate drug or vaccine targets. The availability of complete genome sequences and the establishment of transfection systems for several Babesia species have aided the identification and functional characterization of exported proteins. Here, we review exported Babesia proteins; discuss their functions in the context of immune evasion, cytoadhesion, and nutrient uptake; and highlight possible future topics for research and application in this field. Public Library of Science 2022-09-15 /pmc/articles/PMC9477259/ /pubmed/36107982 http://dx.doi.org/10.1371/journal.ppat.1010770 Text en © 2022 Hakimi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Hakimi, Hassan
Yamagishi, Junya
Kawazu, Shin-ichiro
Asada, Masahito
Advances in understanding red blood cell modifications by Babesia
title Advances in understanding red blood cell modifications by Babesia
title_full Advances in understanding red blood cell modifications by Babesia
title_fullStr Advances in understanding red blood cell modifications by Babesia
title_full_unstemmed Advances in understanding red blood cell modifications by Babesia
title_short Advances in understanding red blood cell modifications by Babesia
title_sort advances in understanding red blood cell modifications by babesia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477259/
https://www.ncbi.nlm.nih.gov/pubmed/36107982
http://dx.doi.org/10.1371/journal.ppat.1010770
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