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An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family
BACKGROUND: Increasing brain exposure of biotherapeutics is key to success in central nervous system disease drug discovery. Accessing the brain parenchyma is especially difficult for large polar molecules such as biotherapeutics and antibodies because of the blood-brain barrier. We investigated a n...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477330/ https://www.ncbi.nlm.nih.gov/pubmed/36108060 http://dx.doi.org/10.1371/journal.pone.0274667 |