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Pan-cancer analysis of co-occurring mutations in RAD52 and the BRCA1-BRCA2-PALB2 axis in human cancers

In human cells homologous recombination (HR) is critical for repair of DNA double strand breaks (DSBs) and rescue of stalled or collapsed replication forks. HR is facilitated by RAD51 which is loaded onto DNA by either BRCA2-BRCA1-PALB2 or RAD52. In human culture cells, double-knockdowns of RAD52 an...

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Detalles Bibliográficos
Autores principales:	Hamid, Abdulaziz B., Frank, Lauren E., Bouley, Renee A., Petreaca, Ruben C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477347/ https://www.ncbi.nlm.nih.gov/pubmed/36107942 http://dx.doi.org/10.1371/journal.pone.0273736

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