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UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide and promoted by PDGF in fibroblast-like synoviocytes: Evidence of a redox control mechanism

UDP-glucose dehydrogenase (UGDH) generates essential precursors of hyaluronic acid (HA) synthesis, however mechanisms regulating its activity are unclear. We used enzyme histostaining and quantitative image analysis to test whether cytokines that stimulate HA synthesis upregulate UGDH activity. Fibr...

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Detalles Bibliográficos
Autores principales:	Chandrasekaran, Ramya, Mathieu, Colleen, Sheth, Rishi, Cheng, Alexandre P., Fong, David, McCormack, Robert, El-Gabalawy, Hani, Alishetty, Suman, Paige, Mikell, Hoemann, Caroline D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477357/ https://www.ncbi.nlm.nih.gov/pubmed/36107941 http://dx.doi.org/10.1371/journal.pone.0274420

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