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Case fatality rate and its determinants among admitted stroke patients in public referral hospitals, Northwest, Ethiopia: A prospective cohort study

According to the global burden of disease 5.5 million deaths were attributable to stroke. The stroke mortality rate is estimated to be seven times higher in low-income countries compared to high-income countries. The main aim of the study was to assess the 28 days case fatality rate and its determin...

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Autores principales: Ayehu, Gashaw Walle, Yitbarek, Getachew Yideg, Jemere, Tadeg, Chanie, Ermias Sisay, Feleke, Dejen Getaneh, Abebaw, Sofonias, Zewde, Edgeit, Atlaw, Daniel, Agegnehu, Assefa, Mamo, Ayele, Degno, Sisay, Azanaw, Melkalem Mamuye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477361/
https://www.ncbi.nlm.nih.gov/pubmed/36108071
http://dx.doi.org/10.1371/journal.pone.0273947
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author Ayehu, Gashaw Walle
Yitbarek, Getachew Yideg
Jemere, Tadeg
Chanie, Ermias Sisay
Feleke, Dejen Getaneh
Abebaw, Sofonias
Zewde, Edgeit
Atlaw, Daniel
Agegnehu, Assefa
Mamo, Ayele
Degno, Sisay
Azanaw, Melkalem Mamuye
author_facet Ayehu, Gashaw Walle
Yitbarek, Getachew Yideg
Jemere, Tadeg
Chanie, Ermias Sisay
Feleke, Dejen Getaneh
Abebaw, Sofonias
Zewde, Edgeit
Atlaw, Daniel
Agegnehu, Assefa
Mamo, Ayele
Degno, Sisay
Azanaw, Melkalem Mamuye
author_sort Ayehu, Gashaw Walle
collection PubMed
description According to the global burden of disease 5.5 million deaths were attributable to stroke. The stroke mortality rate is estimated to be seven times higher in low-income countries compared to high-income countries. The main aim of the study was to assess the 28 days case fatality rate and its determinants among admitted stroke patients in public referral hospitals, in Northwest Ethiopia. A hospital-based prospective cohort study was conducted from December 2020 to June 2021. The study population was 554 stroke patients. Based on Akakian Information Criteria, the Gompertz model was fitted to predict the hazard of death. The study included admitted stroke patients who were treated in the general medical ward and neurology ward. The mean age of the participants was 61 ± 12.85 years and 53.25% of the patients were female. The 28-days case fatality rate of stroke was 27.08%. The results from Gompertz parametric baseline hazard distribution revealed that female sex adjusted hazard rate (AHR = 0.27, 95% CI:0.18–0.42), absence of a family history of chronic disease (AHR = 0.50, 95%CI:0.29–0.87), good GCS score (AHR = 0.21, 95% CI:0.09–0.50) and the absence of complication during hospital admission (AHR = 0.16, 95% CI:0.08–0.29) were factors which decrease hazard of 28 days case fatality rate. While, hemorrhagic stroke sub-type (AHR = 1.38, 95% CI:1.04–3.19), time from symptom onset to hospital arrival (AHR = 1.49, 95% CI:1.57–2 .71), time from confirmation of the diagnosis to initiation of treatment (AHR = 1.03, 95% CI:1.01–1.04), a respiratory rate greater than 20 (AHR = 7.21, 95% CI:3.48–14.9), and increase in NIHSS score (AHR = 1.16, 95% CI:1.10–1.23) were factors increasing hazard of 28 days case fatality rate of stroke. At 28-days follow-up, more than one-fourth of the patients have died. The establishment of separate stroke centers and a network of local and regional stroke centers with expertise in early stroke evaluation and management may address challenges.
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spelling pubmed-94773612022-09-16 Case fatality rate and its determinants among admitted stroke patients in public referral hospitals, Northwest, Ethiopia: A prospective cohort study Ayehu, Gashaw Walle Yitbarek, Getachew Yideg Jemere, Tadeg Chanie, Ermias Sisay Feleke, Dejen Getaneh Abebaw, Sofonias Zewde, Edgeit Atlaw, Daniel Agegnehu, Assefa Mamo, Ayele Degno, Sisay Azanaw, Melkalem Mamuye PLoS One Research Article According to the global burden of disease 5.5 million deaths were attributable to stroke. The stroke mortality rate is estimated to be seven times higher in low-income countries compared to high-income countries. The main aim of the study was to assess the 28 days case fatality rate and its determinants among admitted stroke patients in public referral hospitals, in Northwest Ethiopia. A hospital-based prospective cohort study was conducted from December 2020 to June 2021. The study population was 554 stroke patients. Based on Akakian Information Criteria, the Gompertz model was fitted to predict the hazard of death. The study included admitted stroke patients who were treated in the general medical ward and neurology ward. The mean age of the participants was 61 ± 12.85 years and 53.25% of the patients were female. The 28-days case fatality rate of stroke was 27.08%. The results from Gompertz parametric baseline hazard distribution revealed that female sex adjusted hazard rate (AHR = 0.27, 95% CI:0.18–0.42), absence of a family history of chronic disease (AHR = 0.50, 95%CI:0.29–0.87), good GCS score (AHR = 0.21, 95% CI:0.09–0.50) and the absence of complication during hospital admission (AHR = 0.16, 95% CI:0.08–0.29) were factors which decrease hazard of 28 days case fatality rate. While, hemorrhagic stroke sub-type (AHR = 1.38, 95% CI:1.04–3.19), time from symptom onset to hospital arrival (AHR = 1.49, 95% CI:1.57–2 .71), time from confirmation of the diagnosis to initiation of treatment (AHR = 1.03, 95% CI:1.01–1.04), a respiratory rate greater than 20 (AHR = 7.21, 95% CI:3.48–14.9), and increase in NIHSS score (AHR = 1.16, 95% CI:1.10–1.23) were factors increasing hazard of 28 days case fatality rate of stroke. At 28-days follow-up, more than one-fourth of the patients have died. The establishment of separate stroke centers and a network of local and regional stroke centers with expertise in early stroke evaluation and management may address challenges. Public Library of Science 2022-09-15 /pmc/articles/PMC9477361/ /pubmed/36108071 http://dx.doi.org/10.1371/journal.pone.0273947 Text en © 2022 Ayehu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ayehu, Gashaw Walle
Yitbarek, Getachew Yideg
Jemere, Tadeg
Chanie, Ermias Sisay
Feleke, Dejen Getaneh
Abebaw, Sofonias
Zewde, Edgeit
Atlaw, Daniel
Agegnehu, Assefa
Mamo, Ayele
Degno, Sisay
Azanaw, Melkalem Mamuye
Case fatality rate and its determinants among admitted stroke patients in public referral hospitals, Northwest, Ethiopia: A prospective cohort study
title Case fatality rate and its determinants among admitted stroke patients in public referral hospitals, Northwest, Ethiopia: A prospective cohort study
title_full Case fatality rate and its determinants among admitted stroke patients in public referral hospitals, Northwest, Ethiopia: A prospective cohort study
title_fullStr Case fatality rate and its determinants among admitted stroke patients in public referral hospitals, Northwest, Ethiopia: A prospective cohort study
title_full_unstemmed Case fatality rate and its determinants among admitted stroke patients in public referral hospitals, Northwest, Ethiopia: A prospective cohort study
title_short Case fatality rate and its determinants among admitted stroke patients in public referral hospitals, Northwest, Ethiopia: A prospective cohort study
title_sort case fatality rate and its determinants among admitted stroke patients in public referral hospitals, northwest, ethiopia: a prospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477361/
https://www.ncbi.nlm.nih.gov/pubmed/36108071
http://dx.doi.org/10.1371/journal.pone.0273947
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