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Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization
Thrombin is an enzyme produced during blood coagulation that is crucial to the formation of a stable clot. Thrombin cleaves soluble fibrinogen into fibrin, which polymerizes and forms an insoluble, stabilizing gel around the growing clot. A small fraction of circulating fibrinogen is the variant γ(A...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477365/ https://www.ncbi.nlm.nih.gov/pubmed/36107837 http://dx.doi.org/10.1371/journal.pcbi.1010414 |