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Truncated Tau caused by intron retention is enriched in Alzheimer’s disease cortex and exhibits altered biochemical properties

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β plaques and Tau tangles in brain tissues. Recent studies indicate that aberrant splicing and increased level of intron retention is linked to AD pathogenesis. Bioinformatic analysis revealed increased retention of intron 11 a...

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Detalles Bibliográficos
Autores principales:	Ngian, Zhen-Kai, Tan, Yow-Yong, Choo, Ching-Thong, Lin, Wei-Qi, Leow, Chao-Yong, Mah, Shan-Jie, Lai, Mitchell Kim-Peng, Chen, Christopher Li-Hsian, Ong, Chin-Tong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477417/ https://www.ncbi.nlm.nih.gov/pubmed/36067305 http://dx.doi.org/10.1073/pnas.2204179119

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