Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

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Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component respons...

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Detalles Bibliográficos
Autores principales: Qin, Zhen, Bouteau, Aurélie, Herbst, Christopher, Igyártó, Botond Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477420/
https://www.ncbi.nlm.nih.gov/pubmed/36054264
http://dx.doi.org/10.1371/journal.ppat.1010830

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