Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH

The role of EGFR in lung cancer is well described with numerous activating mutations that result in phosphorylation and tyrosine kinase inhibitors that target EGFR. While the role of the EGFR kinase in non-small cell lung cancer (NSCLC) is appreciated, control of EGFR signaling pathways through deph...

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Detalles Bibliográficos
Autores principales: Swiatnicki, Matthew R., Rennhack, Jonathan P., Ortiz, Mylena M. O., Hollern, Daniel P., Perry, Ashlee V., Kubiak, Rachel, Riveria Riveria, Sarai M., O’Reilly, Sandra, Andrechek, Eran R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477422/
https://www.ncbi.nlm.nih.gov/pubmed/36054194
http://dx.doi.org/10.1371/journal.pgen.1010362

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