Cargando…

RadicalSAM.org: A Resource to Interpret Sequence-Function Space and Discover New Radical SAM Enzyme Chemistry

[Image: see text] The radical SAM superfamily (RSS), arguably the most functionally diverse enzyme superfamily, is also one of the largest with ∼700 K members currently in the UniProt database. The vast majority of the members have uncharacterized enzymatic activities and metabolic functions. In thi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oberg, Nils, Precord, Timothy W., Mitchell, Douglas A., Gerlt, John A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477430/ https://www.ncbi.nlm.nih.gov/pubmed/36119373 http://dx.doi.org/10.1021/acsbiomedchemau.1c00048

Ejemplares similares

Mechanistic and functional versatility of radical SAM enzymes
por: Booker, Squire J, et al.
Publicado: (2010)

Paramagnetic Intermediates Generated by Radical S-Adenosylmethionine (SAM) Enzymes
por: Stich, Troy A., et al.
Publicado: (2014)

Carbon extension in peptidylnucleoside biosynthesis by radical-SAM enzymes
por: Lilla, Edward A., et al.
Publicado: (2016)

Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
por: Beaudoin, Guillaume A. W., et al.
Publicado: (2018)

The vulnerability of radical SAM enzymes to oxidants and soft metals
por: Rohaun, Sanjay Kumar, et al.
Publicado: (2022)

Radical SAM Enzymes Involved in Tetrapyrrole Biosynthesis and Insertion
por: Layer, Gunhild, et al.
Publicado: (2022)

Evolution of Methods for the Study of Cobalamin-Dependent Radical SAM Enzymes
por: Sinner, Erica K., et al.
Publicado: (2021)

Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN
por: Fitzsimmons, Christina M., et al.
Publicado: (2016)

Radical SAM Enzymes and Metallocofactor Assembly: A Structural Point of View
por: Nicolet, Yvain, et al.
Publicado: (2021)

Journey on the Radical SAM Road as an Accidental Pilgrim
por: Bandarian, Vahe
Publicado: (2022)

Structure and Catalytic Mechanism of Radical SAM Methylases
por: Nguyen, Tu-Quynh, et al.
Publicado: (2022)

Twenty Years of Radical SAM! The Genesis of the Superfamily
por: Booker, Squire J., et al.
Publicado: (2022)

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme
por: Shisler, Krista A., et al.
Publicado: (2017)

Characterizing SPASM/twitch Domain-Containing Radical SAM Enzymes by EPR Spectroscopy
por: Balo, Aidin R., et al.
Publicado: (2021)

Evidence for Porphyrin-Mediated Electron Transfer in the Radical SAM Enzyme HutW
por: Brimberry, Marley, et al.
Publicado: (2023)

Radical SAM-dependent ether crosslink in daropeptide biosynthesis
por: Guo, Sijia, et al.
Publicado: (2022)

Eukaryotic TYW1 Is a Radical SAM Flavoenzyme
por: Young, Anthony P., et al.
Publicado: (2021)

A B(12)-dependent radical SAM enzyme involved in Oxetanocin-A biosynthesis
por: Bridwell-Rabb, Jennifer, et al.
Publicado: (2017)

Intermolecular electron transfer in radical SAM enzymes as a new paradigm for reductive activation
por: Eastman, Karsten A.S., et al.
Publicado: (2023)

Structural basis for non-radical catalysis by TsrM, a radical-SAM methylase
por: Knox, Hayley L., et al.
Publicado: (2021)

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS
por: Zhang, Qi, et al.
Publicado: (2011)

Recent Advances in Radical SAM Enzymology: New Structures and Mechanisms
por: Wang, Jiarui, et al.
Publicado: (2014)

Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)
por: Benjdia, Alhosna, et al.
Publicado: (2017)

Analysis of Electrochemical Properties of S-Adenosyl-l-methionine and Implications for Its Role in Radical SAM Enzymes
por: Miller, Sven A., et al.
Publicado: (2019)

Cluster-selective (57)Fe labeling of a Twitch-domain-containing radical SAM enzyme
por: Namkoong, Gil, et al.
Publicado: (2023)

C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase
por: Gui, Jinghan, et al.
Publicado: (2014)

Computational Approaches: An Underutilized Tool in the Quest to Elucidate Radical SAM Dynamics
por: Blue, Tamra C., et al.
Publicado: (2021)

Crystallographic snapshots of a B(12)-dependent radical SAM methyltransferase
por: Fyfe, Cameron D., et al.
Publicado: (2022)

Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation
por: Mathew, Liju G., et al.
Publicado: (2021)

On the Role of Additional [4Fe-4S] Clusters with a Free Coordination Site in Radical-SAM Enzymes
por: Mulliez, Etienne, et al.
Publicado: (2017)

Radical SAM Enzymes and Ribosomally‐Synthesized and Post‐translationally Modified Peptides: A Growing Importance in the Microbiomes
por: Benjdia, Alhosna, et al.
Publicado: (2021)

The Function of Two Radical‐SAM Enzymes, HcgA and HcgG, in the Biosynthesis of the [Fe]‐Hydrogenase Cofactor
por: Arriaza‐Gallardo, Francisco J., et al.
Publicado: (2022)

Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase
por: Fenwick, Michael K., et al.
Publicado: (2015)

Correction to “Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation”
por: Mathew, Liju G., et al.
Publicado: (2022)

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
por: Benjdia, Alhosna, et al.
Publicado: (2012)

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism
por: Dowling, Daniel P., et al.
Publicado: (2013)

Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes
por: Balty, Clémence, et al.
Publicado: (2021)

Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii
por: Padgett, Leah R., et al.
Publicado: (2018)

The B(12)-Radical SAM Enzyme PoyC Catalyzes Valine C(β)-Methylation during Polytheonamide Biosynthesis
por: Parent, Aubérie, et al.
Publicado: (2016)

Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK
por: Lichstrahl, Michael S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_erg73rk6faiqep2aus4ujtp9g6