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Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo

OBJECTIVE: The present study aimed to determine whether residual dizziness (RD) after successful repositioning treatment in benign paroxysmal positional vertigo (BPPV) patients could be predicted by red blood cell distribution width (RDW). MATERIALS AND METHODS: In this study, a total of 303 BBPV pa...

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Autores principales: Xie, Ke-Hang, Chen, Li-Chun, Liu, Ling-Ling, Su, Chu-Yin, Li, Hua, Liu, Run-Ni, Chen, Qing-Qing, He, Jia-Sheng, Ruan, Yong-Kun, He, Wang-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477442/
https://www.ncbi.nlm.nih.gov/pubmed/36119686
http://dx.doi.org/10.3389/fneur.2022.857133
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author Xie, Ke-Hang
Chen, Li-Chun
Liu, Ling-Ling
Su, Chu-Yin
Li, Hua
Liu, Run-Ni
Chen, Qing-Qing
He, Jia-Sheng
Ruan, Yong-Kun
He, Wang-Kai
author_facet Xie, Ke-Hang
Chen, Li-Chun
Liu, Ling-Ling
Su, Chu-Yin
Li, Hua
Liu, Run-Ni
Chen, Qing-Qing
He, Jia-Sheng
Ruan, Yong-Kun
He, Wang-Kai
author_sort Xie, Ke-Hang
collection PubMed
description OBJECTIVE: The present study aimed to determine whether residual dizziness (RD) after successful repositioning treatment in benign paroxysmal positional vertigo (BPPV) patients could be predicted by red blood cell distribution width (RDW). MATERIALS AND METHODS: In this study, a total of 303 BBPV patients hospitalized at the neurology department were investigated. The enrolled patients were divided into two groups after successful repositioning treatment: non-RD group included patients who were completely cured, and RD group included patients with RD. We collected data on all subjects, including general information, blood routine examination, blood biochemical examination, and magnetic resonance imaging tests. RESULTS: The mean RDW values of patients in the RD group were significantly higher than that in the non-RD group (13.63 ± 1.8 vs. 12.5 ± 0.8; p < 0.001). In subsequent multivariate analysis, elevated RDW levels were a statistically significant risk factor associated with the occurrence of RD [odds ratio = 2.62, 95% confidence interval (CI) 1.88–3.64, p < 0.001]. The area under the ROC curve was 0.723 in terms of its predictive ability to distinguish patients with RD. A cut-off point of 12.95% of RDW predicted RD with a sensitivity of 75.6% and a specificity of 69.5%. Moreover, the AUC for the ability of the RDW to predict recurrence were 0.692 (95% CI = 0.561–0.831; p < 0.014). CONCLUSIONS: Elevated RDW level was related to increased risk of RD among BPPV patients, requiring further efforts to clarify the actual underlying pathophysiology.
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spelling pubmed-94774422022-09-16 Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo Xie, Ke-Hang Chen, Li-Chun Liu, Ling-Ling Su, Chu-Yin Li, Hua Liu, Run-Ni Chen, Qing-Qing He, Jia-Sheng Ruan, Yong-Kun He, Wang-Kai Front Neurol Neurology OBJECTIVE: The present study aimed to determine whether residual dizziness (RD) after successful repositioning treatment in benign paroxysmal positional vertigo (BPPV) patients could be predicted by red blood cell distribution width (RDW). MATERIALS AND METHODS: In this study, a total of 303 BBPV patients hospitalized at the neurology department were investigated. The enrolled patients were divided into two groups after successful repositioning treatment: non-RD group included patients who were completely cured, and RD group included patients with RD. We collected data on all subjects, including general information, blood routine examination, blood biochemical examination, and magnetic resonance imaging tests. RESULTS: The mean RDW values of patients in the RD group were significantly higher than that in the non-RD group (13.63 ± 1.8 vs. 12.5 ± 0.8; p < 0.001). In subsequent multivariate analysis, elevated RDW levels were a statistically significant risk factor associated with the occurrence of RD [odds ratio = 2.62, 95% confidence interval (CI) 1.88–3.64, p < 0.001]. The area under the ROC curve was 0.723 in terms of its predictive ability to distinguish patients with RD. A cut-off point of 12.95% of RDW predicted RD with a sensitivity of 75.6% and a specificity of 69.5%. Moreover, the AUC for the ability of the RDW to predict recurrence were 0.692 (95% CI = 0.561–0.831; p < 0.014). CONCLUSIONS: Elevated RDW level was related to increased risk of RD among BPPV patients, requiring further efforts to clarify the actual underlying pathophysiology. Frontiers Media S.A. 2022-09-01 /pmc/articles/PMC9477442/ /pubmed/36119686 http://dx.doi.org/10.3389/fneur.2022.857133 Text en Copyright © 2022 Xie, Chen, Liu, Su, Li, Liu, Chen, He, Ruan and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Xie, Ke-Hang
Chen, Li-Chun
Liu, Ling-Ling
Su, Chu-Yin
Li, Hua
Liu, Run-Ni
Chen, Qing-Qing
He, Jia-Sheng
Ruan, Yong-Kun
He, Wang-Kai
Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo
title Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo
title_full Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo
title_fullStr Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo
title_full_unstemmed Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo
title_short Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo
title_sort elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477442/
https://www.ncbi.nlm.nih.gov/pubmed/36119686
http://dx.doi.org/10.3389/fneur.2022.857133
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