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A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia
CONTEXT: Kniphofia (Asphodelaceae) is found mainly in South Africa and Tropical Africa. Malaria, hepatitis B, blood purifier, cancer, eczema, and female infertility have all been traditionally treated using this genus. OBJECTIVE: The current review provides a complete and up-to-date compilation of d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477484/ https://www.ncbi.nlm.nih.gov/pubmed/35701101 http://dx.doi.org/10.1080/13880209.2022.2085753 |
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author | Nigussie, Gashaw Tegegn, Metasebia Abeje, Dessalegn Melak, Haregua |
author_facet | Nigussie, Gashaw Tegegn, Metasebia Abeje, Dessalegn Melak, Haregua |
author_sort | Nigussie, Gashaw |
collection | PubMed |
description | CONTEXT: Kniphofia (Asphodelaceae) is found mainly in South Africa and Tropical Africa. Malaria, hepatitis B, blood purifier, cancer, eczema, and female infertility have all been traditionally treated using this genus. OBJECTIVE: The current review provides a complete and up-to-date compilation of documented traditional medicinal uses, phytochemicals, and pharmacological activities of the genus. METHOD: Relevant literature was collected by searching the major electronic scientific databases including PubMed, Science Direct, Web of Science, and Google Scholar using appropriate keywords ethnomedicinal studies, phytochemical investigations, and pharmacological activities of Kniphofia species. The search strategy included all articles with descriptors that were available until November 30, 2021. Only published works in English were used for this study. The data were collected using textual descriptions of the studies, tabulation, grouping, and figures. RESULT: At present, more than 40 compounds have been isolated from different parts of Kniphofia species. The major compounds isolated from the Kniphofia species are monomeric anthraquinones and dimeric anthraquinones. Pharmacologically the extracts and isolated compounds showed antioxidant, antimalarial, antiproliferative, anti-HIV-1, anti-leukotriene, and cytotoxic activity. The genus afforded exemplary drug leads such as knipholone and knipholone anthrone with anti-HIV-1, antimalarial and cytotoxicity activity. CONCLUSIONS: Kniphofia species have traditionally been used to treat a variety of diseases. Pharmacological actions of phytochemicals were shown to be promising. Despite this, considering the genus's inclusion on the red data list of South Africa, it deserves more attention. In order to find novel drug candidates, more studies on promising crude extracts and compounds are needed. |
format | Online Article Text |
id | pubmed-9477484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-94774842022-09-16 A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia Nigussie, Gashaw Tegegn, Metasebia Abeje, Dessalegn Melak, Haregua Pharm Biol Research Article CONTEXT: Kniphofia (Asphodelaceae) is found mainly in South Africa and Tropical Africa. Malaria, hepatitis B, blood purifier, cancer, eczema, and female infertility have all been traditionally treated using this genus. OBJECTIVE: The current review provides a complete and up-to-date compilation of documented traditional medicinal uses, phytochemicals, and pharmacological activities of the genus. METHOD: Relevant literature was collected by searching the major electronic scientific databases including PubMed, Science Direct, Web of Science, and Google Scholar using appropriate keywords ethnomedicinal studies, phytochemical investigations, and pharmacological activities of Kniphofia species. The search strategy included all articles with descriptors that were available until November 30, 2021. Only published works in English were used for this study. The data were collected using textual descriptions of the studies, tabulation, grouping, and figures. RESULT: At present, more than 40 compounds have been isolated from different parts of Kniphofia species. The major compounds isolated from the Kniphofia species are monomeric anthraquinones and dimeric anthraquinones. Pharmacologically the extracts and isolated compounds showed antioxidant, antimalarial, antiproliferative, anti-HIV-1, anti-leukotriene, and cytotoxic activity. The genus afforded exemplary drug leads such as knipholone and knipholone anthrone with anti-HIV-1, antimalarial and cytotoxicity activity. CONCLUSIONS: Kniphofia species have traditionally been used to treat a variety of diseases. Pharmacological actions of phytochemicals were shown to be promising. Despite this, considering the genus's inclusion on the red data list of South Africa, it deserves more attention. In order to find novel drug candidates, more studies on promising crude extracts and compounds are needed. Taylor & Francis 2022-06-14 /pmc/articles/PMC9477484/ /pubmed/35701101 http://dx.doi.org/10.1080/13880209.2022.2085753 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nigussie, Gashaw Tegegn, Metasebia Abeje, Dessalegn Melak, Haregua A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia |
title | A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia |
title_full | A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia |
title_fullStr | A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia |
title_full_unstemmed | A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia |
title_short | A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia |
title_sort | comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus kniphofia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477484/ https://www.ncbi.nlm.nih.gov/pubmed/35701101 http://dx.doi.org/10.1080/13880209.2022.2085753 |
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