SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis

The emergence of a novel coronavirus, COVID-19, in December 2019 led to a global pandemic with more than 170 million confirmed infections and more than 6 million deaths (by July 2022). Studies have shown that infection with SARS-CoV-2 in cancer patients has a higher mortality rate than in people wit...

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Autores principales: Mozaffari, Shahrooz Amin, Salehi, Ali, Mousavi, Elnaz, Zaman, Burhan Abdullah, Nassaj, Ali Eslambol, Ebrahimzadeh, Farnoosh, Nasiri, Hadi, Valedkarimi, Zahra, Adili, Ali, Asemani, Ghazaleh, Akbari, Morteza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier GmbH. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477615/
https://www.ncbi.nlm.nih.gov/pubmed/36191449
http://dx.doi.org/10.1016/j.prp.2022.154131
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author Mozaffari, Shahrooz Amin
Salehi, Ali
Mousavi, Elnaz
Zaman, Burhan Abdullah
Nassaj, Ali Eslambol
Ebrahimzadeh, Farnoosh
Nasiri, Hadi
Valedkarimi, Zahra
Adili, Ali
Asemani, Ghazaleh
Akbari, Morteza
author_facet Mozaffari, Shahrooz Amin
Salehi, Ali
Mousavi, Elnaz
Zaman, Burhan Abdullah
Nassaj, Ali Eslambol
Ebrahimzadeh, Farnoosh
Nasiri, Hadi
Valedkarimi, Zahra
Adili, Ali
Asemani, Ghazaleh
Akbari, Morteza
author_sort Mozaffari, Shahrooz Amin
collection PubMed
description The emergence of a novel coronavirus, COVID-19, in December 2019 led to a global pandemic with more than 170 million confirmed infections and more than 6 million deaths (by July 2022). Studies have shown that infection with SARS-CoV-2 in cancer patients has a higher mortality rate than in people without cancer. Here, we have reviewed the evidence showing that gut microbiota plays an important role in health and is linked to colorectal cancer development. Studies have shown that SARS-CoV-2 infection leads to a change in gut microbiota, which modify intestinal inflammation and barrier permeability and affects tumor-suppressor or oncogene genes, proposing SARS-CoV-2 as a potential contributor to CRC pathogenesis
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spelling pubmed-94776152022-09-16 SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis Mozaffari, Shahrooz Amin Salehi, Ali Mousavi, Elnaz Zaman, Burhan Abdullah Nassaj, Ali Eslambol Ebrahimzadeh, Farnoosh Nasiri, Hadi Valedkarimi, Zahra Adili, Ali Asemani, Ghazaleh Akbari, Morteza Pathol Res Pract Review The emergence of a novel coronavirus, COVID-19, in December 2019 led to a global pandemic with more than 170 million confirmed infections and more than 6 million deaths (by July 2022). Studies have shown that infection with SARS-CoV-2 in cancer patients has a higher mortality rate than in people without cancer. Here, we have reviewed the evidence showing that gut microbiota plays an important role in health and is linked to colorectal cancer development. Studies have shown that SARS-CoV-2 infection leads to a change in gut microbiota, which modify intestinal inflammation and barrier permeability and affects tumor-suppressor or oncogene genes, proposing SARS-CoV-2 as a potential contributor to CRC pathogenesis Elsevier GmbH. 2022-11 2022-09-16 /pmc/articles/PMC9477615/ /pubmed/36191449 http://dx.doi.org/10.1016/j.prp.2022.154131 Text en © 2022 Elsevier GmbH. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Mozaffari, Shahrooz Amin
Salehi, Ali
Mousavi, Elnaz
Zaman, Burhan Abdullah
Nassaj, Ali Eslambol
Ebrahimzadeh, Farnoosh
Nasiri, Hadi
Valedkarimi, Zahra
Adili, Ali
Asemani, Ghazaleh
Akbari, Morteza
SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis
title SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis
title_full SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis
title_fullStr SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis
title_full_unstemmed SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis
title_short SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis
title_sort sars-cov-2-associated gut microbiome alteration; a new contributor to colorectal cancer pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477615/
https://www.ncbi.nlm.nih.gov/pubmed/36191449
http://dx.doi.org/10.1016/j.prp.2022.154131
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