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Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome

Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in the development of metabolic syndrome (MS). The purpose of this study was to analyse the frequency with which polymorphic loci of adiponectin (ADIPOQ) and leptin (LEP) genes occur in patients with MS and t...

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Autores principales: Shramko, Iuliana I., Ageeva, Elizaveta S., Maliy, Konstantin D., Repinskaya, Irina N., Tarimov, Cyrill O., Fomochkina, Iryna I., Kubishkin, Anatolii V., Ostapenko, Olga V., Gurtovaya, Anna K., Shekhar, Suman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477633/
https://www.ncbi.nlm.nih.gov/pubmed/36117520
http://dx.doi.org/10.1155/2022/9881422
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author Shramko, Iuliana I.
Ageeva, Elizaveta S.
Maliy, Konstantin D.
Repinskaya, Irina N.
Tarimov, Cyrill O.
Fomochkina, Iryna I.
Kubishkin, Anatolii V.
Ostapenko, Olga V.
Gurtovaya, Anna K.
Shekhar, Suman
author_facet Shramko, Iuliana I.
Ageeva, Elizaveta S.
Maliy, Konstantin D.
Repinskaya, Irina N.
Tarimov, Cyrill O.
Fomochkina, Iryna I.
Kubishkin, Anatolii V.
Ostapenko, Olga V.
Gurtovaya, Anna K.
Shekhar, Suman
author_sort Shramko, Iuliana I.
collection PubMed
description Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in the development of metabolic syndrome (MS). The purpose of this study was to analyse the frequency with which polymorphic loci of adiponectin (ADIPOQ) and leptin (LEP) genes occur in patients with MS and the association between the symptoms of MS and these polymorphisms. DNA was isolated from the whole blood of 207 patients with MS and 100 healthy individuals (control group) using the phenol-chloroform method. Gene polymorphisms were determined using real-time polymerase chain reaction (PCR). The most common variant of the ADIPOQ (rs2241766) gene among MS patients was the GT genotype. The A allele of the LEP (rs7799039) gene was found to be the most frequent in MS patients. The highest systolic blood pressure was found in carriers of the GG genotype of the LEP (rs7799039) gene. The carriers of the ADIPOQ (rs2241766) GT genotype were associated with the highest systolic blood pressure and body mass index (BMI); carriers of the ADIPOQ (rs2241766) GG genotype were associated with the highest diastolic blood pressure, hyperglycaemia, and elevated glycated haemoglobin (HbA1c). The results of this study allowed us to establish the unique gene variants associated with the risk of developing MS in the Crimean population.
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spelling pubmed-94776332022-09-16 Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome Shramko, Iuliana I. Ageeva, Elizaveta S. Maliy, Konstantin D. Repinskaya, Irina N. Tarimov, Cyrill O. Fomochkina, Iryna I. Kubishkin, Anatolii V. Ostapenko, Olga V. Gurtovaya, Anna K. Shekhar, Suman J Diabetes Res Research Article Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in the development of metabolic syndrome (MS). The purpose of this study was to analyse the frequency with which polymorphic loci of adiponectin (ADIPOQ) and leptin (LEP) genes occur in patients with MS and the association between the symptoms of MS and these polymorphisms. DNA was isolated from the whole blood of 207 patients with MS and 100 healthy individuals (control group) using the phenol-chloroform method. Gene polymorphisms were determined using real-time polymerase chain reaction (PCR). The most common variant of the ADIPOQ (rs2241766) gene among MS patients was the GT genotype. The A allele of the LEP (rs7799039) gene was found to be the most frequent in MS patients. The highest systolic blood pressure was found in carriers of the GG genotype of the LEP (rs7799039) gene. The carriers of the ADIPOQ (rs2241766) GT genotype were associated with the highest systolic blood pressure and body mass index (BMI); carriers of the ADIPOQ (rs2241766) GG genotype were associated with the highest diastolic blood pressure, hyperglycaemia, and elevated glycated haemoglobin (HbA1c). The results of this study allowed us to establish the unique gene variants associated with the risk of developing MS in the Crimean population. Hindawi 2022-09-08 /pmc/articles/PMC9477633/ /pubmed/36117520 http://dx.doi.org/10.1155/2022/9881422 Text en Copyright © 2022 Iuliana I. Shramko et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shramko, Iuliana I.
Ageeva, Elizaveta S.
Maliy, Konstantin D.
Repinskaya, Irina N.
Tarimov, Cyrill O.
Fomochkina, Iryna I.
Kubishkin, Anatolii V.
Ostapenko, Olga V.
Gurtovaya, Anna K.
Shekhar, Suman
Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome
title Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome
title_full Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome
title_fullStr Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome
title_full_unstemmed Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome
title_short Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome
title_sort association between adiponectin and leptin receptor genetic polymorphisms and clinical manifestations of metabolic syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477633/
https://www.ncbi.nlm.nih.gov/pubmed/36117520
http://dx.doi.org/10.1155/2022/9881422
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