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Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report
BACKGROUND: Burkitt-like lymphoma with 11q aberration (BLL-11q) is a rare provisional lymphoma, and the majority of cases are usually diagnosed by excisional lymph node biopsy. Here we report a case of BLL-11q diagnosed by needle biopsy of the liver in order to improve further understanding of the d...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477696/ https://www.ncbi.nlm.nih.gov/pubmed/36159440 http://dx.doi.org/10.12998/wjcc.v10.i26.9470 |
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author | Yang, Han-Jin Wang, Zhao-Ming |
author_facet | Yang, Han-Jin Wang, Zhao-Ming |
author_sort | Yang, Han-Jin |
collection | PubMed |
description | BACKGROUND: Burkitt-like lymphoma with 11q aberration (BLL-11q) is a rare provisional lymphoma, and the majority of cases are usually diagnosed by excisional lymph node biopsy. Here we report a case of BLL-11q diagnosed by needle biopsy of the liver in order to improve further understanding of the disease, reduce misdiagnosis, and identify treatment regimens. CASE SUMMARY: The patient was a 67-year-old male. He complained of increased frequency of stools for more than one year, periumbilical pain and discomfort exceeding 3 mo. A computed tomography scan suggested an appendiceal malignant tumor with multiple metastases of the peritoneum, omentum, and liver. Needle biopsy of liver nodules showed that the tumor cells were of median size, the shape was consistent, a small number of tumor cells were large, the “starry sky” pattern was evident, and some tissue cells showed multiple apoptotic debris with coarse particles. Immunohistochemistry was positive for CD20, CD10, BCL6, and MYC. The Ki-67 proliferation index was more than 95%. Molecular biological detection indicated a lack of MYC, BCL2 and BCL6 gene rearrangement with 11q aberration. Therefore, the diagnosis was BLL-11q of the liver. After eight courses of chemotherapy, the abdominal and pelvic peritoneal masses and liver nodules had almost disappeared. The patient recovered well after a follow-up period of more than 13 mo. CONCLUSION: BLL-11q is rare, but patients treated with standard chemotherapy for Burkitt lymphoma can have a good prognosis. Reducing the dose of chemotherapy or developing specific therapies to prevent overtreatment may be considered, but more case studies are needed. |
format | Online Article Text |
id | pubmed-9477696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-94776962022-09-23 Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report Yang, Han-Jin Wang, Zhao-Ming World J Clin Cases Case Report BACKGROUND: Burkitt-like lymphoma with 11q aberration (BLL-11q) is a rare provisional lymphoma, and the majority of cases are usually diagnosed by excisional lymph node biopsy. Here we report a case of BLL-11q diagnosed by needle biopsy of the liver in order to improve further understanding of the disease, reduce misdiagnosis, and identify treatment regimens. CASE SUMMARY: The patient was a 67-year-old male. He complained of increased frequency of stools for more than one year, periumbilical pain and discomfort exceeding 3 mo. A computed tomography scan suggested an appendiceal malignant tumor with multiple metastases of the peritoneum, omentum, and liver. Needle biopsy of liver nodules showed that the tumor cells were of median size, the shape was consistent, a small number of tumor cells were large, the “starry sky” pattern was evident, and some tissue cells showed multiple apoptotic debris with coarse particles. Immunohistochemistry was positive for CD20, CD10, BCL6, and MYC. The Ki-67 proliferation index was more than 95%. Molecular biological detection indicated a lack of MYC, BCL2 and BCL6 gene rearrangement with 11q aberration. Therefore, the diagnosis was BLL-11q of the liver. After eight courses of chemotherapy, the abdominal and pelvic peritoneal masses and liver nodules had almost disappeared. The patient recovered well after a follow-up period of more than 13 mo. CONCLUSION: BLL-11q is rare, but patients treated with standard chemotherapy for Burkitt lymphoma can have a good prognosis. Reducing the dose of chemotherapy or developing specific therapies to prevent overtreatment may be considered, but more case studies are needed. Baishideng Publishing Group Inc 2022-09-16 2022-09-16 /pmc/articles/PMC9477696/ /pubmed/36159440 http://dx.doi.org/10.12998/wjcc.v10.i26.9470 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Yang, Han-Jin Wang, Zhao-Ming Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report |
title | Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report |
title_full | Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report |
title_fullStr | Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report |
title_full_unstemmed | Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report |
title_short | Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report |
title_sort | burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477696/ https://www.ncbi.nlm.nih.gov/pubmed/36159440 http://dx.doi.org/10.12998/wjcc.v10.i26.9470 |
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