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Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021

BACKGROUND: Very limited information is available on SARS-CoV-2 seroprevalence in infants in sub-Saharan countries. OBJECTIVE: In this study, we aimed to determine the rate and the temporal evolution of SARS CoV-2 seropositivity in breastfed Malawian infants. STUDY DESIGN: Blood samples (n = 250) fr...

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Autores principales: Baroncelli, Silvia, Galluzzo, Clementina Maria, Orlando, Stefano, Mphwere, Robert, Kavalo, Thom, Luhanga, Richard, Amici, Roberta, Floridia, Marco, Andreotti, Mauro, Scarcella, Paola, Marazzi, Maria Cristina, Giuliano, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477783/
https://www.ncbi.nlm.nih.gov/pubmed/36128323
http://dx.doi.org/10.1016/j.jcvp.2022.100110
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author Baroncelli, Silvia
Galluzzo, Clementina Maria
Orlando, Stefano
Mphwere, Robert
Kavalo, Thom
Luhanga, Richard
Amici, Roberta
Floridia, Marco
Andreotti, Mauro
Scarcella, Paola
Marazzi, Maria Cristina
Giuliano, Marina
author_facet Baroncelli, Silvia
Galluzzo, Clementina Maria
Orlando, Stefano
Mphwere, Robert
Kavalo, Thom
Luhanga, Richard
Amici, Roberta
Floridia, Marco
Andreotti, Mauro
Scarcella, Paola
Marazzi, Maria Cristina
Giuliano, Marina
author_sort Baroncelli, Silvia
collection PubMed
description BACKGROUND: Very limited information is available on SARS-CoV-2 seroprevalence in infants in sub-Saharan countries. OBJECTIVE: In this study, we aimed to determine the rate and the temporal evolution of SARS CoV-2 seropositivity in breastfed Malawian infants. STUDY DESIGN: Blood samples (n = 250) from 158 infants, born to HIV-negative women and women living with HIV, collected from February 2020 to May 2021, were first tested using an Anti-IgG/A/M SARS CoV 2 ELISA assay against trimeric spike protein, and then, if positive, confirmed using a second ELISA assay detecting IgG against Receptor Binding Domain. RESULTS: The confirmed prevalence of anti-SARS CoV-2 antibodies was 31.0% (95% CI: 23.7%-38.3%) with no significant difference between HIV-exposed and HIV-unexposed infants (29.3% and 37.1% respectively, P = 0.410). The presence of anti-SARS-CoV-2 IgG was not associated with maternal socioeconomic or demographic indices. CONCLUSIONS: Our data underline the wide spread of the SARS-CoV-2 infection in the pediatric population in sub-Saharan Africa. Design of more specific serological tests for African samples and improvements in serosurveillance programs are needed for more rigorous monitoring of the dynamics of SARS-CoV-2 infection in Africa.
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spelling pubmed-94777832022-09-16 Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021 Baroncelli, Silvia Galluzzo, Clementina Maria Orlando, Stefano Mphwere, Robert Kavalo, Thom Luhanga, Richard Amici, Roberta Floridia, Marco Andreotti, Mauro Scarcella, Paola Marazzi, Maria Cristina Giuliano, Marina J Clin Virol Plus Article BACKGROUND: Very limited information is available on SARS-CoV-2 seroprevalence in infants in sub-Saharan countries. OBJECTIVE: In this study, we aimed to determine the rate and the temporal evolution of SARS CoV-2 seropositivity in breastfed Malawian infants. STUDY DESIGN: Blood samples (n = 250) from 158 infants, born to HIV-negative women and women living with HIV, collected from February 2020 to May 2021, were first tested using an Anti-IgG/A/M SARS CoV 2 ELISA assay against trimeric spike protein, and then, if positive, confirmed using a second ELISA assay detecting IgG against Receptor Binding Domain. RESULTS: The confirmed prevalence of anti-SARS CoV-2 antibodies was 31.0% (95% CI: 23.7%-38.3%) with no significant difference between HIV-exposed and HIV-unexposed infants (29.3% and 37.1% respectively, P = 0.410). The presence of anti-SARS-CoV-2 IgG was not associated with maternal socioeconomic or demographic indices. CONCLUSIONS: Our data underline the wide spread of the SARS-CoV-2 infection in the pediatric population in sub-Saharan Africa. Design of more specific serological tests for African samples and improvements in serosurveillance programs are needed for more rigorous monitoring of the dynamics of SARS-CoV-2 infection in Africa. The Authors. Published by Elsevier Ltd. 2022-11 2022-09-16 /pmc/articles/PMC9477783/ /pubmed/36128323 http://dx.doi.org/10.1016/j.jcvp.2022.100110 Text en © 2022 The Authors. Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Baroncelli, Silvia
Galluzzo, Clementina Maria
Orlando, Stefano
Mphwere, Robert
Kavalo, Thom
Luhanga, Richard
Amici, Roberta
Floridia, Marco
Andreotti, Mauro
Scarcella, Paola
Marazzi, Maria Cristina
Giuliano, Marina
Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021
title Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021
title_full Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021
title_fullStr Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021
title_full_unstemmed Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021
title_short Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021
title_sort dynamics of sars-cov-2 exposure in malawian infants between february 2020 and may 2021
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477783/
https://www.ncbi.nlm.nih.gov/pubmed/36128323
http://dx.doi.org/10.1016/j.jcvp.2022.100110
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