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Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy

Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are characterized by d...

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Detalles Bibliográficos
Autores principales: Zhang, Su, Meng, Yang, Zhou, Lian, Qiu, Lei, Wang, Heping, Su, Dan, Zhang, Bo, Chan, Kui‐Ming, Han, Junhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477794/
https://www.ncbi.nlm.nih.gov/pubmed/36176733
http://dx.doi.org/10.1002/mco2.173
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author Zhang, Su
Meng, Yang
Zhou, Lian
Qiu, Lei
Wang, Heping
Su, Dan
Zhang, Bo
Chan, Kui‐Ming
Han, Junhong
author_facet Zhang, Su
Meng, Yang
Zhou, Lian
Qiu, Lei
Wang, Heping
Su, Dan
Zhang, Bo
Chan, Kui‐Ming
Han, Junhong
author_sort Zhang, Su
collection PubMed
description Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses, leading to excessive and uncontrol tissue inflammation. The dysregulation of epigenetic alterations including DNA methylation, posttranslational modifications to histone proteins, and noncoding RNA expression has been implicated in a host of inflammatory disorders and the immune system. The inflammatory response is considered as a critical trigger of epigenetic alterations that in turn intercede inflammatory actions. Thus, understanding the molecular mechanism that dictates the outcome of targeting epigenetic regulators for inflammatory disease is required for inflammation resolution. In this article, we elucidate the critical role of the nuclear factor‐κB signaling pathway, JAK/STAT signaling pathway, and the NLRP3 inflammasome in chronic inflammatory diseases. And we formulate the relationship between inflammation, coronavirus disease 2019, and human cancers. Additionally, we review the mechanism of epigenetic modifications involved in inflammation and innate immune cells. All that matters is that we propose and discuss the rejuvenation potential of interventions that target epigenetic regulators and regulatory mechanisms for chronic inflammation‐associated diseases to improve therapeutic outcomes.
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spelling pubmed-94777942022-09-28 Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy Zhang, Su Meng, Yang Zhou, Lian Qiu, Lei Wang, Heping Su, Dan Zhang, Bo Chan, Kui‐Ming Han, Junhong MedComm (2020) Reviews Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses, leading to excessive and uncontrol tissue inflammation. The dysregulation of epigenetic alterations including DNA methylation, posttranslational modifications to histone proteins, and noncoding RNA expression has been implicated in a host of inflammatory disorders and the immune system. The inflammatory response is considered as a critical trigger of epigenetic alterations that in turn intercede inflammatory actions. Thus, understanding the molecular mechanism that dictates the outcome of targeting epigenetic regulators for inflammatory disease is required for inflammation resolution. In this article, we elucidate the critical role of the nuclear factor‐κB signaling pathway, JAK/STAT signaling pathway, and the NLRP3 inflammasome in chronic inflammatory diseases. And we formulate the relationship between inflammation, coronavirus disease 2019, and human cancers. Additionally, we review the mechanism of epigenetic modifications involved in inflammation and innate immune cells. All that matters is that we propose and discuss the rejuvenation potential of interventions that target epigenetic regulators and regulatory mechanisms for chronic inflammation‐associated diseases to improve therapeutic outcomes. John Wiley and Sons Inc. 2022-09-15 /pmc/articles/PMC9477794/ /pubmed/36176733 http://dx.doi.org/10.1002/mco2.173 Text en © 2022 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Zhang, Su
Meng, Yang
Zhou, Lian
Qiu, Lei
Wang, Heping
Su, Dan
Zhang, Bo
Chan, Kui‐Ming
Han, Junhong
Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
title Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
title_full Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
title_fullStr Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
title_full_unstemmed Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
title_short Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
title_sort targeting epigenetic regulators for inflammation: mechanisms and intervention therapy
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477794/
https://www.ncbi.nlm.nih.gov/pubmed/36176733
http://dx.doi.org/10.1002/mco2.173
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