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The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction

Epidemiological studies have suggested that cold is an important contributor to acute cardiovascular events and mortality. However, little is known about the Diurnal Temperature Range (DTR) impact on mortality of the patients with myocardial infarction. Calcium ions (Ca(2+)) play a vital role in the...

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Autores principales: Gu, Xingbo, Liu, Dandan, Hao, Ning, Sun, Xinyong, Liu, Shulei, Duan, Xiaoxu, Yang, Shuang, Li, Jia, Wang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477801/
https://www.ncbi.nlm.nih.gov/pubmed/36109534
http://dx.doi.org/10.1038/s41598-022-18816-2
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author Gu, Xingbo
Liu, Dandan
Hao, Ning
Sun, Xinyong
Liu, Shulei
Duan, Xiaoxu
Yang, Shuang
Li, Jia
Wang, Shu
author_facet Gu, Xingbo
Liu, Dandan
Hao, Ning
Sun, Xinyong
Liu, Shulei
Duan, Xiaoxu
Yang, Shuang
Li, Jia
Wang, Shu
author_sort Gu, Xingbo
collection PubMed
description Epidemiological studies have suggested that cold is an important contributor to acute cardiovascular events and mortality. However, little is known about the Diurnal Temperature Range (DTR) impact on mortality of the patients with myocardial infarction. Calcium ions (Ca(2+)) play a vital role in the human body, such as cardiac electrophysiology and contraction. To investigate whether DTR on admission moderates the association between serum calcium and in-hospital mortality in patients with acute myocardial infarction (AMI). This retrospective study enrolled consecutive adult patients with AMI at a single center in China (2003–2012). Patients were divided into four groups (Ca-Q1–4) according to serum calcium concentration quartiles. Multivariate logistic regression modeling was used to assess whether DTR moderated the association between serum calcium and in-hospital mortality. The predictive value of serum calcium was evaluated by receiver operating characteristic (ROC) curve and net reclassification improvement (NRI) analyses. The study included 3780 patients. In-hospital mortality was 4.97% (188/3780). DTR moderated the association between serum calcium and in-hospital mortality (P-interaction = 0.020). Patients with low serum calcium in the highest DTR quartile exhibited an increased risk of in-hospital mortality (odds ratio for Ca-Q4 vs. Ca-Q1, 0.03; 95% confidence interval [95% CI], 0.01–0.20). In the highest DTR quartile, adding serum calcium concentration to the risk factor model increased the area under the ROC curve (0.81 vs. 0.76; P < 0.001) and increased NRI by 20.2% (95% CI 7.5–32.9; P = 0.001). Low serum calcium was an independent risk factor for in-hospital mortality in patients with AMI, and this association was moderated by DTR. Careful attention should be paid to patients with low serum calcium who experience a higher DTR on admission.
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spelling pubmed-94778012022-09-17 The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction Gu, Xingbo Liu, Dandan Hao, Ning Sun, Xinyong Liu, Shulei Duan, Xiaoxu Yang, Shuang Li, Jia Wang, Shu Sci Rep Article Epidemiological studies have suggested that cold is an important contributor to acute cardiovascular events and mortality. However, little is known about the Diurnal Temperature Range (DTR) impact on mortality of the patients with myocardial infarction. Calcium ions (Ca(2+)) play a vital role in the human body, such as cardiac electrophysiology and contraction. To investigate whether DTR on admission moderates the association between serum calcium and in-hospital mortality in patients with acute myocardial infarction (AMI). This retrospective study enrolled consecutive adult patients with AMI at a single center in China (2003–2012). Patients were divided into four groups (Ca-Q1–4) according to serum calcium concentration quartiles. Multivariate logistic regression modeling was used to assess whether DTR moderated the association between serum calcium and in-hospital mortality. The predictive value of serum calcium was evaluated by receiver operating characteristic (ROC) curve and net reclassification improvement (NRI) analyses. The study included 3780 patients. In-hospital mortality was 4.97% (188/3780). DTR moderated the association between serum calcium and in-hospital mortality (P-interaction = 0.020). Patients with low serum calcium in the highest DTR quartile exhibited an increased risk of in-hospital mortality (odds ratio for Ca-Q4 vs. Ca-Q1, 0.03; 95% confidence interval [95% CI], 0.01–0.20). In the highest DTR quartile, adding serum calcium concentration to the risk factor model increased the area under the ROC curve (0.81 vs. 0.76; P < 0.001) and increased NRI by 20.2% (95% CI 7.5–32.9; P = 0.001). Low serum calcium was an independent risk factor for in-hospital mortality in patients with AMI, and this association was moderated by DTR. Careful attention should be paid to patients with low serum calcium who experience a higher DTR on admission. Nature Publishing Group UK 2022-09-15 /pmc/articles/PMC9477801/ /pubmed/36109534 http://dx.doi.org/10.1038/s41598-022-18816-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gu, Xingbo
Liu, Dandan
Hao, Ning
Sun, Xinyong
Liu, Shulei
Duan, Xiaoxu
Yang, Shuang
Li, Jia
Wang, Shu
The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction
title The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction
title_full The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction
title_fullStr The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction
title_full_unstemmed The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction
title_short The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction
title_sort synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477801/
https://www.ncbi.nlm.nih.gov/pubmed/36109534
http://dx.doi.org/10.1038/s41598-022-18816-2
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