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STING mediates nuclear PD-L1 targeting-induced senescence in cancer cells

Immune checkpoint molecule programmed death-ligand 1 (PD-L1) is overexpressed in cancer cells and imparts resistance to cancer therapy. Although membrane PD-L1 has been targeted for cancer immune therapy, nuclear PD-L1 was reported to confer cancer resistance. Therefore, it is important to regulate...

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Detalles Bibliográficos
Autores principales:	Lee, Je-Jung, Kim, So Young, Kim, Songhee H., Choi, Seoyeon, Lee, Bin, Shin, Jeon-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477807/ https://www.ncbi.nlm.nih.gov/pubmed/36109513 http://dx.doi.org/10.1038/s41419-022-05217-6

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